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MetaCyc Reaction: 4.2.1.144

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.2.1.144

Enzymes and Genes:

Amycolatopsis mediterranei : 3-amino-5-hydroxybenzoate synthase Inferred from experiment : rifK

In Pathway: 3-amino-5-hydroxybenzoate biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-amino-5-hydroxybenzoate synthase

Enzyme Commission Synonyms: AHBA synthase, rifK (gene name)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -12.581127 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal 5'-phosphate enzyme. The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-α-D-kanosamine [Floss11].

Citations: [Kim98a, Eads99]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R06595

Relationship Links: BRENDA:EC:4.2.1.144 , ENZYME:EC:4.2.1.144 , IUBMB-ExplorEnz:EC:4.2.1.144


References

Eads99: Eads JC, Beeby M, Scapin G, Yu TW, Floss HG (1999). "Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase." Biochemistry 38(31);9840-9. PMID: 10433690

Floss11: Floss HG, Yu TW, Arakawa K (2011). "The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review." J Antibiot (Tokyo) 64(1);35-44. PMID: 21081954

Kim98a: Kim CG, Yu TW, Fryhle CB, Handa S, Floss HG (1998). "3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics." J Biol Chem 273(11);6030-40. PMID: 9497318

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Aug 3, 2015, BIOCYC14A.