|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
In Pathway: 3-amino-5-hydroxybenzoate biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 3-amino-5-hydroxybenzoate synthase
Enzyme Commission Synonyms: AHBA synthase, rifK (gene name)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -12.581127 [Latendresse13]
Enzyme Commission Summary:
A pyridoxal 5'-phosphate enzyme. The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-α-D-kanosamine [Floss11].
Unification Links: KEGG:R06595
Floss11: Floss HG, Yu TW, Arakawa K (2011). "The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review." J Antibiot (Tokyo) 64(1);35-44. PMID: 21081954
Kim98a: Kim CG, Yu TW, Fryhle CB, Handa S, Floss HG (1998). "3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics." J Biol Chem 273(11);6030-40. PMID: 9497318
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