|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Arabidopsis thaliana col:||long-chain acyl-CoA synthetase 9: LACS9|
|Homo sapiens:||long-chain-fatty-acid--CoA ligase 1: ACSL1|
|Saccharomyces cerevisiae:||medium-chain acyl-CoA synthetase: FAA2|
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: long-chain-fatty-acid—CoA ligase
Enzyme Commission Synonyms: acyl-CoA synthetase, fatty acid thiokinase (long chain), acyl-activating enzyme, palmitoyl-CoA synthase, lignoceroyl-CoA synthase, arachidonyl-CoA synthetase, acyl coenzyme A synthetase, acyl-CoA ligase, palmitoyl coenzyme A synthetase, thiokinase, palmitoyl-CoA ligase, acyl-coenzyme A ligase, fatty acid CoA ligase, long-chain fatty acyl coenzyme A synthetase, oleoyl-CoA synthetase, stearoyl-CoA synthetase, long chain fatty acyl-CoA synthetase, long-chain acyl CoA synthetase, fatty acid elongase, LCFA synthetase, pristanoyl-CoA synthetase, ACS3, long-chain acyl-CoA synthetase I, long-chain acyl-CoA synthetase II, fatty acyl-coenzyme A synthetase, long-chain acyl-coenzyme A synthetase, FAA1
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -12.711731 [Latendresse13]
Enzyme Commission Summary:
Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
Hosaka79: Hosaka K, Mishina M, Tanaka T, Kamiryo T, Numa S (1979). "Acyl-coenzyme-A synthetase I from Candida lipolytica. Purification, properties and immunochemical studies." Eur J Biochem 93(1);197-203. PMID: 108099
Nagamatsu85: Nagamatsu K, Soeda S, Mori M, Kishimoto Y (1985). "Lignoceroyl-coenzyme A synthetase from developing rat brain: partial purification, characterization and comparison with palmitoyl-coenzyme A synthetase activity and liver enzyme." Biochim Biophys Acta 836(1);80-8. PMID: 3161545
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