|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: long-chain-fatty-acid—CoA ligase
Enzyme Commission Synonyms: acyl-CoA synθse, fatty acid thiokinase (long chain), acyl-activating enzyme, palmitoyl-CoA synthase, lignoceroyl-CoA synthase, arachidonyl-CoA synθse, acyl coenzyme A synθse, acyl-CoA ligase, palmitoyl coenzyme A synθse, thiokinase, palmitoyl-CoA ligase, acyl-coenzyme A ligase, fatty acid CoA ligase, long-chain fatty acyl coenzyme A synθse, oleoyl-CoA synθse, stearoyl-CoA synθse, long chain fatty acyl-CoA synθse, long-chain acyl CoA synθse, fatty acid elongase, LCFA synθse, pristanoyl-CoA synθse, ACS3, long-chain acyl-CoA synθse I, long-chain acyl-CoA synθse II, fatty acyl-coenzyme A synθse, long-chain acyl-coenzyme A synθse, FAA1
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -12.711731 [Latendresse13]
Enzyme Commission Summary:
Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
Instance reactions of [a 2,3,4-saturated fatty acid + ATP + coenzyme A → a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate] (22.214.171.124):
i2: phytanate + ATP + coenzyme A → phytanoyl-CoA + AMP + diphosphate (126.96.36.199)
i3: octanoate + ATP + coenzyme A → octanoyl-CoA + AMP + diphosphate (188.8.131.52)
i4: decanoate + ATP + coenzyme A → decanoyl-CoA + AMP + diphosphate (184.108.40.206)
i5: hexanoate + ATP + coenzyme A → hexanoyl-CoA + AMP + diphosphate (6.2.1.-)
i6: pristanate + ATP + coenzyme A → pristanoyl-CoA + AMP + diphosphate (220.127.116.11)
Instance reaction of [a long-chain fatty acid + ATP + coenzyme A → a long-chain acyl-CoA + AMP + diphosphate] (18.104.22.168):
i1: palmitate + ATP + coenzyme A → palmitoyl-CoA + AMP + diphosphate (22.214.171.124)
Hosaka79: Hosaka K, Mishina M, Tanaka T, Kamiryo T, Numa S (1979). "Acyl-coenzyme-A synthetase I from Candida lipolytica. Purification, properties and immunochemical studies." Eur J Biochem 93(1);197-203. PMID: 108099
Nagamatsu85: Nagamatsu K, Soeda S, Mori M, Kishimoto Y (1985). "Lignoceroyl-coenzyme A synthetase from developing rat brain: partial purification, characterization and comparison with palmitoyl-coenzyme A synthetase activity and liver enzyme." Biochim Biophys Acta 836(1);80-8. PMID: 3161545
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