MetaCyc Reaction: 1.14.13.-

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.14.13.-

Enzymes and Genes:

Arabidopsis thaliana col: fatty acid ω-hydroxylaseInferred from experiment: CYP94C1
long-chain fatty acid ω-hydroxylase: CYP704B1
Glycine max: long-chain fatty acid ω-hydroxylaseInferred from experiment
Starmerella bombicola: long-chain fatty acid ω/(ω-1) hydroxylase: CYP52M1

In Pathway: cutin biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a long-chain fatty acid + NADPH + oxygen + H+ → an ω-hydroxy long-chain fatty acid + NADP+ + H2O (

Enzyme Commission Primary Name: 1.14.13 -- With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Standard Gibbs Free Energy (ΔrG in kcal/mol): -88.65054Inferred by computational analysis [Latendresse13]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a long-chain fatty acid + NADPH + oxygen + H+ → an ω-hydroxy long-chain fatty acid + NADP+ + H2O] (
i1: stearate + NADPH + oxygen + H+ → 18-hydroxystearate + NADP+ + H2O (

i2: palmitate + NADPH + oxygen + H+ → 16-hydroxypalmitate + NADP+ + H2O (

i3: oleate + NADPH + oxygen + H+ → 18-hydroxyoleate + NADP+ + H2O (

i4: (9R,10S)-dihydroxystearate + NADPH + oxygen + H+ → 9,10,18-trihydroxystearate + NADP+ + H2O (1.14.13.-)

i5: 9,10-epoxystearate + NADPH + oxygen + H+ → 9,10-epoxy-18-hydroxystearate + NADP+ + H2O (1.14.13.-)
i6: docosahexaenoate + NADPH + H+ + oxygen → 22-hydroxydocosahexaenoate + NADP+ + H2O (


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc14.