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MetaCyc Reaction: 1.14.13.-

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.13.-

Enzymes and Genes:

Arabidopsis thaliana col : fatty acid ω-hydroxylase Inferred from experiment : CYP94C1
long-chain fatty acid ω-hydroxylase : CYP704B1
Glycine max : long-chain fatty acid ω-hydroxylase Inferred from experiment
Starmerella bombicola : long-chain fatty acid ω/(ω-1) hydroxylase : CYP52M1

In Pathway: cutin biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a long-chain fatty acid + NADPH + oxygen + H+ → an ω-hydroxy long-chain fatty acid + NADP+ + H2O (1.14.13.cs)

Enzyme Commission Primary Name: 1.14.13 -- With NADH or NADPH as one donor, and incorporation of one atom of oxygen

Standard Gibbs Free Energy (ΔrG in kcal/mol): -88.65054 Inferred by computational analysis [Latendresse13]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [a long-chain fatty acid + NADPH + oxygen + H+ → an ω-hydroxy long-chain fatty acid + NADP+ + H2O] (1.14.13.cs):
i1: palmitate + NADPH + oxygen + H+ → 16-hydroxypalmitate + NADP+ + H2O (1.14.13.cs)

i2: (9R,10S)-dihydroxystearate + NADPH + oxygen + H+ → 9,10,18-trihydroxystearate + NADP+ + H2O (1.14.13.-)

i3: docosahexaenoate + NADPH + H+ + oxygen → 22-hydroxydocosahexaenoate + NADP+ + H2O (1.14.13.199)

i4: oleate + NADPH + oxygen + H+ → 18-hydroxyoleate + NADP+ + H2O (1.14.13.cs)

i5: 9,10-epoxystearate + NADPH + oxygen + H+ → 9,10-epoxy-18-hydroxystearate + NADP+ + H2O (1.14.13.-)
i6: stearate + NADPH + oxygen + H+ → 18-hydroxystearate + NADP+ + H2O (1.14.13.cs)


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Jul 29, 2015, BIOCYC13B.