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MetaCyc Reaction: 5.1.99.4

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 5.1.99.4

Enzymes and Genes:

Homo sapiens: α-methylacyl-CoA racemase: AMACR
Rattus norvegicus: α-methylacyl-CoA racemaseInferred from experiment: Amacr

In Pathway: bile acid biosynthesis, neutral pathway

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: α-methylacyl-CoA racemase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.0Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
α-methyl-branched acyl-CoA derivatives with chain lengths of more than C10 are substrates. Also active towards some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA. Not active towards free acids.

Citations: [Schmitz94]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R08739

Relationship Links: BRENDA:EC:5.1.99.4, ENZYME:EC:5.1.99.4, IUBMB-ExplorEnz:EC:5.1.99.4


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Schmitz94: Schmitz W, Fingerhut R, Conzelmann E (1994). "Purification and properties of an alpha-methylacyl-CoA racemase from rat liver." Eur J Biochem 222(2);313-23. PMID: 8020470


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun May 1, 2016, biocyc11.