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MetaCyc Reaction: 5.1.99.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 5.1.99.4

Enzymes and Genes:

Homo sapiens : α-methylacyl-CoA racemase : AMACR
Rattus norvegicus : α-methylacyl-CoA racemase Inferred from experiment : Amacr

In Pathway: bile acid biosynthesis, neutral pathway

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: α-methylacyl-CoA racemase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.0 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
α-methyl-branched acyl-CoA derivatives with chain lengths of more than C10 are substrates. Also active towards some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA. Not active towards free acids.

Citations: [Schmitz94]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R08739

Relationship Links: BRENDA:EC:5.1.99.4 , ENZYME:EC:5.1.99.4 , IUBMB-ExplorEnz:EC:5.1.99.4


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Schmitz94: Schmitz W, Fingerhut R, Conzelmann E (1994). "Purification and properties of an alpha-methylacyl-CoA racemase from rat liver." Eur J Biochem 222(2);313-23. PMID: 8020470


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Aug 30, 2015, biocyc13.