MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Cupriavidus sp. PS12: chloromuconate cycloisomeraseInferred from experiment
Pseudomonas knackmussii: chloromuconate cycloisomeraseInferred from experiment: clcB
Pseudomonas reinekei: muconate cycloisomerase IInferred from experiment: salC
Pseudomonas sp. P51: chloromuconate cycloisomeraseInferred from experiment: tcbD
Ralstonia eutropha JMP134: chloromuconate cycloisomerase IInferred from experiment: tfdDI
chloromuconate cycloisomerase IIInferred from experiment: tfdDII

In Pathway: chlorosalicylate degradation, 4-chlorocatechol degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: chloromuconate cycloisomerase

Enzyme Commission Synonyms: muconate cycloisomerase II

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.9617538Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-dienelactone. Also acts (in the reverse direction) on 2-chloro-cis,cis-muconate. Not identical with EC (muconate cycloisomerase) or EC (dichloromuconate cycloisomerase).

Citations: [Schmidt80, Kaulmann01]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R04259, Rhea:11035

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Kaulmann01: Kaulmann U, Kaschabek SR, Schlomann M (2001). "Mechanism of chloride elimination from 3-chloro- and 2,4-dichloro-cis,cis-muconate: new insight obtained from analysis of muconate cycloisomerase variant CatB-K169A." J Bacteriol 183(15);4551-61. PMID: 11443090

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Schmidt80: Schmidt E, Knackmuss HJ (1980). "Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid." Biochem J 192(1);339-47. PMID: 7305906

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc14.