|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Enzymes and Genes:
|Pseudomonas reinekei :||muconate cycloisomerase I
In Pathway: chlorosalicylate degradation
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: chloromuconate cycloisomerase
Enzyme Commission Synonyms: muconate cycloisomerase II
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 1.9617538 [Latendresse13]
Enzyme Commission Summary:
Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts (in the reverse direction) on 2-chloro-cis,cis-muconate. Not identical with EC 220.127.116.11 (muconate cycloisomerase) or EC 18.104.22.168 (dichloromuconate cycloisomerase).
Kaulmann01: Kaulmann U, Kaschabek SR, Schlomann M (2001). "Mechanism of chloride elimination from 3-chloro- and 2,4-dichloro-cis,cis-muconate: new insight obtained from analysis of muconate cycloisomerase variant CatB-K169A." J Bacteriol 183(15);4551-61. PMID: 11443090
Schmidt80: Schmidt E, Knackmuss HJ (1980). "Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid." Biochem J 192(1);339-47. PMID: 7305906
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