|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
chloromuconate cycloisomerase ( Cupriavidus sp. PS12 )
chloromuconate cycloisomerase II : tfdDII ( Ralstonia eutropha JMP134 )
chloromuconate cycloisomerase : tcbD ( Pseudomonas sp. P51 )
chloromuconate cycloisomerase : clcB ( Pseudomonas knackmussii )
chloromuconate cycloisomerase I : tfdDI ( Ralstonia eutropha JMP134 )
In Pathway: 4-chlorocatechol degradation
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: chloromuconate cycloisomerase
Enzyme Commission Synonyms: muconate cycloisomerase II
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -7.4241257 [Latendresse13]
Enzyme Commission Summary:
Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts (in the reverse direction) on 2-chloro-cis,cis-muconate. Not identical with EC 22.214.171.124 (muconate cycloisomerase) or EC 126.96.36.199 (dichloromuconate cycloisomerase).
Unification Links: KEGG:R05391
Schmidt80: Schmidt E, Knackmuss HJ (1980). "Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid." Biochem J 192(1);339-47. PMID: 7305906
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