MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Cupriavidus sp. PS12 : chloromuconate cycloisomerase Inferred from experiment
Pseudomonas knackmussii : chloromuconate cycloisomerase Inferred from experiment : clcB
Pseudomonas sp. P51 : chloromuconate cycloisomerase Inferred from experiment : tcbD
Ralstonia eutropha JMP134 : chloromuconate cycloisomerase I Inferred from experiment : tfdDI
chloromuconate cycloisomerase II Inferred from experiment : tfdDII

In Pathway: 4-chlorocatechol degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: chloromuconate cycloisomerase

Enzyme Commission Synonyms: muconate cycloisomerase II

Standard Gibbs Free Energy (ΔrG in kcal/mol): -7.4241257 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts (in the reverse direction) on 2-chloro-cis,cis-muconate. Not identical with EC (muconate cycloisomerase) or EC (dichloromuconate cycloisomerase).

Citations: [Schmidt80]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R05391

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Schmidt80: Schmidt E, Knackmuss HJ (1980). "Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid." Biochem J 192(1);339-47. PMID: 7305906

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jul 28, 2015, BIOCYC14A.