|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Pseudomonas reinekei :||salicylate 1-hydroxylase
In Pathway: chlorosalicylate degradation
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: salicylate 1-monooxygenase
Enzyme Commission Synonyms: salicylate hydroxylase, salicylate 1-hydroxylase, salicylate monooxygenase, salicylate hydroxylase (decarboxylating)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -92.624695 [Latendresse13]
Enzyme Commission Summary:
A flavoprotein (FAD).
Nikodem03: Nikodem P, Hecht V, Schlomann M, Pieper DH (2003). "New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1." J Bacteriol 185(23);6790-800. PMID: 14617643
Takemori69: Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex." Biochim Biophys Acta 191(1);58-68. PMID: 4898626
Takemori69a: Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin." Biochim Biophys Acta 191(1);69-76. PMID: 4309912
Uzuki69: Uzuki K, Takemori S, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation." Biochim Biophys Acta 191(1);77-85. PMID: 4390441
Yamamoto65: Yamamoto, S., Katagiri, M., Maeno, H., Hayaishi, O. (1965). "Salicylate hydroxylase, a monooxygenase requiring flavin adenine dinucleotide. I. Purification and general properties." J Biol Chem 240: 3408-13. PMID: 14321380
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