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MetaCyc Reaction: 1.14.13.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.13.1

Enzymes and Genes:

Pseudomonas reinekei : salicylate 1-hydroxylase Inferred from experiment : salA

In Pathway: chlorosalicylate degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: salicylate 1-monooxygenase

Enzyme Commission Synonyms: salicylate hydroxylase, salicylate 1-hydroxylase, salicylate monooxygenase, salicylate hydroxylase (decarboxylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -92.624695 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD).

Citations: [Nikodem03, Uzuki69, Takemori69, Takemori69a, Yamamoto65]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:1.14.13.1 , ENZYME:EC:1.14.13.1 , IUBMB-ExplorEnz:EC:1.14.13.1


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nikodem03: Nikodem P, Hecht V, Schlomann M, Pieper DH (2003). "New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1." J Bacteriol 185(23);6790-800. PMID: 14617643

Takemori69: Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex." Biochim Biophys Acta 191(1);58-68. PMID: 4898626

Takemori69a: Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin." Biochim Biophys Acta 191(1);69-76. PMID: 4309912

Uzuki69: Uzuki K, Takemori S, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation." Biochim Biophys Acta 191(1);77-85. PMID: 4390441

Yamamoto65: Yamamoto, S., Katagiri, M., Maeno, H., Hayaishi, O. (1965). "Salicylate hydroxylase, a monooxygenase requiring flavin adenine dinucleotide. I. Purification and general properties." J Biol Chem 240: 3408-13. PMID: 14321380


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Apr 25, 2015, biocyc14.