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MetaCyc Reaction: 1.14.13.1

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.14.13.1

Enzymes and Genes:

Pseudomonas reinekei: salicylate 1-hydroxylaseInferred from experiment: salA

In Pathway: chlorosalicylate degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: salicylate 1-monooxygenase

Enzyme Commission Synonyms: salicylate hydroxylase, salicylate 1-hydroxylase, salicylate monooxygenase, salicylate hydroxylase (decarboxylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -92.624695Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD).

Citations: [Nikodem03, Uzuki69, Takemori69, Takemori69a, Yamamoto65]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:1.14.13.1, ENZYME:EC:1.14.13.1, IUBMB-ExplorEnz:EC:1.14.13.1


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nikodem03: Nikodem P, Hecht V, Schlomann M, Pieper DH (2003). "New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1." J Bacteriol 185(23);6790-800. PMID: 14617643

Takemori69: Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex." Biochim Biophys Acta 191(1);58-68. PMID: 4898626

Takemori69a: Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin." Biochim Biophys Acta 191(1);69-76. PMID: 4309912

Uzuki69: Uzuki K, Takemori S, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation." Biochim Biophys Acta 191(1);77-85. PMID: 4390441

Yamamoto65: Yamamoto, S., Katagiri, M., Maeno, H., Hayaishi, O. (1965). "Salicylate hydroxylase, a monooxygenase requiring flavin adenine dinucleotide. I. Purification and general properties." J Biol Chem 240: 3408-13. PMID: 14321380


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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