|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
Enzymes and Genes:
|Pseudomonas reinekei:||salicylate 1-hydroxylase: salA|
In Pathway: chlorosalicylate degradation
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: salicylate 1-monooxygenase
Enzyme Commission Synonyms: salicylate hydroxylase, salicylate 1-hydroxylase, salicylate monooxygenase, salicylate hydroxylase (decarboxylating)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -92.624695 [Latendresse13]
Enzyme Commission Summary:
A flavoprotein (FAD).
Nikodem03: Nikodem P, Hecht V, Schlomann M, Pieper DH (2003). "New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1." J Bacteriol 185(23);6790-800. PMID: 14617643
Takemori69: Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex." Biochim Biophys Acta 191(1);58-68. PMID: 4898626
Takemori69a: Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin." Biochim Biophys Acta 191(1);69-76. PMID: 4309912
Uzuki69: Uzuki K, Takemori S, Katagiri M (1969). "Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation." Biochim Biophys Acta 191(1);77-85. PMID: 4390441
Yamamoto65: Yamamoto, S., Katagiri, M., Maeno, H., Hayaishi, O. (1965). "Salicylate hydroxylase, a monooxygenase requiring flavin adenine dinucleotide. I. Purification and general properties." J Biol Chem 240: 3408-13. PMID: 14321380
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