|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: ferredoxin:thioredoxin reductase
Enzyme Commission Synonyms: ferredoxin:thioredoxin disulfide oxidoreductase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -9.900482 [Latendresse13]
Enzyme Commission Summary:
Contains a [4Fe-4S] cluster and internal disulfide. It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC 22.214.171.124 (fructose-1,6-bisphosphatase), EC 126.96.36.199 (sedoheptulose-bisphosphatase) and EC 188.8.131.52 (phosphoribulokinase) as well as other chloroplast enzymes by disulfide reduction.
Buchanan91: Buchanan BB (1991). "Regulation of CO2 assimilation in oxygenic photosynthesis: the ferredoxin/thioredoxin system. Perspective on its discovery, present status, and future development." Arch Biochem Biophys 288(1);1-9. PMID: 1910303
Chow95: Chow LP, Iwadate H, Yano K, Kamo M, Tsugita A, Gardet-Salvi L, Stritt-Etter AL, Schurmann P (1995). "Amino acid sequence of spinach ferredoxin:thioredoxin reductase catalytic subunit and identification of thiol groups constituting a redox-active disulfide and a [4Fe-4S] cluster." Eur J Biochem 231(1);149-56. PMID: 7628465
Staples96: Staples CR, Ameyibor E, Fu W, Gardet-Salvi L, Stritt-Etter AL, Schurmann P, Knaff DB, Johnson MK (1996). "The function and properties of the iron-sulfur center in spinach ferredoxin: thioredoxin reductase: a new biological role for iron-sulfur clusters." Biochemistry 35(35);11425-34. PMID: 8784198
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