MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:

Synechocystis sp. PCC 6803: ferredoxin-thioredoxin reductaseInferred from experiment: ftrV, ftrC

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ferredoxin:thioredoxin reductase

Enzyme Commission Synonyms: ferredoxin:thioredoxin disulfide oxidoreductase

Taxonomic Range: Bacteria , Viridiplantae

Standard Gibbs Free Energy (ΔrG in kcal/mol): -9.900482Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Contains a [4Fe-4S] cluster and internal disulfide. It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC (fructose-1,6-bisphosphatase), EC (sedoheptulose-bisphosphatase) and EC (phosphoribulokinase) as well as other chloroplast enzymes by disulfide reduction.

Citations: [Buchanan91, Chow95, Staples96]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R09502

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 16-Mar-2010 by Caspi R, SRI International


Buchanan91: Buchanan BB (1991). "Regulation of CO2 assimilation in oxygenic photosynthesis: the ferredoxin/thioredoxin system. Perspective on its discovery, present status, and future development." Arch Biochem Biophys 288(1);1-9. PMID: 1910303

Chow95: Chow LP, Iwadate H, Yano K, Kamo M, Tsugita A, Gardet-Salvi L, Stritt-Etter AL, Schurmann P (1995). "Amino acid sequence of spinach ferredoxin:thioredoxin reductase catalytic subunit and identification of thiol groups constituting a redox-active disulfide and a [4Fe-4S] cluster." Eur J Biochem 231(1);149-56. PMID: 7628465

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Staples96: Staples CR, Ameyibor E, Fu W, Gardet-Salvi L, Stritt-Etter AL, Schurmann P, Knaff DB, Johnson MK (1996). "The function and properties of the iron-sulfur center in spinach ferredoxin: thioredoxin reductase: a new biological role for iron-sulfur clusters." Biochemistry 35(35);11425-34. PMID: 8784198

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sat Nov 28, 2015, BIOCYC13A.