|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
|Escherichia coli K-12 substr. MG1655:||multicopper oxidase with role in copper homeostasis: cueO|
|Homo sapiens:||ceruloplasmin: CP|
Reaction Locations: periplasm (sensu Gram-negative Bacteria), cytosol
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: ferroxidase
Enzyme Commission Synonyms: ceruloplasmin, caeruloplasmin, ferroxidase I, iron oxidase, iron(II):oxygen oxidoreductase, ferro:O2 oxidoreductase, iron II:oxygen oxidoreductase, hephaestin, HEPH
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -13.166946 [Latendresse13]
Enzyme Commission Summary:
The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a.
Chen04: Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, Fox TC, Usta J, Naylor CE, Evans RW, McKie AT, Anderson GJ, Vulpe CD (2004). "Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice." Blood 103(10);3933-9. PMID: 14751926
Osaki67: Osaki S, Walaas O (1967). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex." J Biol Chem 242(11);2653-7. PMID: 6027241
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