MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: acetaldehyde dehydrogenaseInferred from experiment: aldB
NADPH-dependent aldehyde reductase: yqhD
Saccharomyces cerevisiae: magnesium-activated aldehyde dehydrogenase, cytosolicInferred from experiment: ALD6
potassium-activated aldehyde dehydrogenase, mitochondrial: ALD4
aldehyde dehydrogenase, mitochondrial: ALD5

In Pathway: pyruvate fermentation to acetate VIII, NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (NADP+)

Enzyme Commission Synonyms: NADP-acetaldehyde dehydrogenase, NADP-dependent aldehyde dehydrogenase, aldehyde dehydrogenase (NADP)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -16.52362Inferred by computational analysis [Latendresse13]

Citations: [Seegmiller53]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NADP+ + H2O → a carboxylate + NADPH + 2 H+] (
i1: acetaldehyde + NADP+ + H2O → acetate + NADPH + 2 H+ (

Unification Links: KEGG:R00711, Rhea:25298

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Seegmiller53: Seegmiller JE (1953). "Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast." J Biol Chem 201(2);629-37. PMID: 13061400

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun Nov 29, 2015, BIOCYC13A.