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MetaCyc Reaction: 1.2.1.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.4

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : acetaldehyde dehydrogenase Inferred from experiment : aldB
NADPH-dependent aldehyde reductase : yqhD
Saccharomyces cerevisiae : magnesium-activated aldehyde dehydrogenase, cytosolic Inferred from experiment : ALD6
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4
aldehyde dehydrogenase, mitochondrial : ALD5

In Pathway: pyruvate fermentation to acetate VIII , NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (NADP+)

Enzyme Commission Synonyms: NADP-acetaldehyde dehydrogenase, NADP-dependent aldehyde dehydrogenase, aldehyde dehydrogenase (NADP)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -16.52362 Inferred by computational analysis [Latendresse13]

Citations: [Seegmiller53]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NADP+ + H2O → a carboxylate + NADPH + 2 H+] (1.2.1.4):
i1: acetaldehyde + NADP+ + H2O → acetate + NADPH + 2 H+ (1.2.1.4)

Unification Links: KEGG:R00711 , Rhea:25298

Relationship Links: BRENDA:EC:1.2.1.4 , ENZYME:EC:1.2.1.4 , IUBMB-ExplorEnz:EC:1.2.1.4


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Seegmiller53: Seegmiller JE (1953). "Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast." J Biol Chem 201(2);629-37. PMID: 13061400


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Sep 1, 2015, biocyc14.