Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.2.1.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.4

Enzymes and Genes:
acetaldehyde dehydrogenase Inferred from experiment : aldB ( Escherichia coli K-12 substr. MG1655 )
magnesium-activated aldehyde dehydrogenase, cytosolic Inferred from experiment : ALD6 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase, mitochondrial : ALD5 ( Saccharomyces cerevisiae )
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4 ( Saccharomyces cerevisiae )
NADPH-dependent aldehyde reductase : yqhD ( Escherichia coli K-12 substr. MG1655 )

In Pathway: pyruvate fermentation to acetate VIII , NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (NADP+)

Enzyme Commission Synonyms: NADP-acetaldehyde dehydrogenase, NADP-dependent aldehyde dehydrogenase, aldehyde dehydrogenase (NADP)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -16.52362 Inferred by computational analysis [Latendresse13]

Citations: [Seegmiller53]

Gene-Reaction Schematic: ?

Instance reaction of [an aldehyde + NADP+ + H2O → a carboxylate + NADPH + 2 H+] (1.2.1.4):
i1: acetaldehyde + NADP+ + H2O → acetate + NADPH + 2 H+ (1.2.1.4)

Unification Links: KEGG:R00711 , Rhea:25298

Relationship Links: BRENDA:EC:1.2.1.4 , ENZYME:EC:1.2.1.4 , IUBMB-ExplorEnz:EC:1.2.1.4


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Seegmiller53: Seegmiller JE (1953). "Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast." J Biol Chem 201(2);629-37. PMID: 13061400


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13B.