MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Anabaena variabilis : uptake hydrogenase Inferred from experiment : hupL , hupS
Cupriavidus necator : [NiFe]-hydrogenase (membrane bound) Inferred from experiment : hoxZ , hoxK , hoxG
Rhodospirillum rubrum : carbon monoxide induced hydrogenase Inferred from experiment : cooH , cooU , cooX , cooL , cooK , cooM

Sub-reaction of:
1.2.99.-: carbon monoxide + H2O = CO2 + H2

In Pathway: hydrogen oxidation I (aerobic) , hydrogen production VI

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: hydrogenase (acceptor)

Enzyme Commission Synonyms: H2 producing hydrogenase[ambiguous], hydrogen-lyase[ambiguous], hydrogenlyase[ambiguous], uptake hydrogenase[ambiguous], hydrogen:(acceptor) oxidoreductase

Enzyme Commission Summary:
Uses molecular hydrogen for the reduction of a variety of substances. Contains iron-sulfur clusters. The enzyme from some sources contains nickel.

Citations: [Adams80, Vignais01]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R07182 , Rhea:12116

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Revised 09-Dec-2011 by Caspi R , SRI International


Adams80: Adams MW, Mortenson LE, Chen JS (1980). "Hydrogenase." Biochim Biophys Acta 594(2-3);105-76. PMID: 6786341

Vignais01: Vignais PM, Billoud B, Meyer J (2001). "Classification and phylogeny of hydrogenases." FEMS Microbiol Rev 25(4);455-501. PMID: 11524134

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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