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MetaCyc Reaction: 3.6.1.-

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.6.1.-

Enzymes and Genes:

Aquifex aeolicus VF5: nucleoside-triphosphatase: THEP1
Escherichia coli K-12 substr. MG1655: XTPaseInferred from experiment: yjjX
Homo sapiens: cancer-related nucleoside-triphosphatase: NTPCR
Pisum sativum: nucleoside-triphosphatase: NTP1

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3.6.1 -- In phosphorous-containing anhydrides

Standard Gibbs Free Energy (ΔrG in kcal/mol): -102.58893Inferred by computational analysis [Latendresse13]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a nucleoside triphosphate + H2O → a nucleoside diphosphate + phosphate + H+] (3.6.1.15):
i1: ATP + H2O → ADP + phosphate + H+ (3.6.1.3/3.6.1.15/3.6.4.6)

i2: dATP + H2O → dADP + phosphate + H+ (no EC#)

i3: dCTP + H2O → dCDP + phosphate + H+ (no EC#)

i4: dGTP + H2O → dGDP + phosphate + H+ (no EC#)

i5: dUTP + H2O → dUDP + phosphate + H+ (no EC#)

i6: dTTP + H2O → dTDP + phosphate + H+ (3.6.1.39)

i7: GTP + H2O → GDP + phosphate + H+ (3.6.1.15/3.6.5.1/3.6.5.2/3.6.5.3/3.6.5.4/3.6.5.5/3.6.5.6)

i8: UTP + H2O = UDP + phosphate + H+ (3.6.1.15)

i9: CTP + H2O → CDP + phosphate + H+ (3.6.1.15)

i10: ITP + H2O → IDP + phosphate + H+ (3.6.1.-)

i11: XTP + H2O → XDP + phosphate + H+ (3.6.1.-)

Unification Links: Rhea:28406


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Feb 9, 2016, biocyc14.