MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite ReactionsElectron-Transfer-Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: hydrogenase 1, oxygen tolerant hydrogenaseInferred from experiment: hyaC, hyaB, hyaA
hydrogenase 2Inferred from experiment: hybA, hybB, hybO, hybC

In Pathway: hydrogen to fumarate electron transfer, hydrogen to dimethyl sulfoxide electron transfer, hydrogen to trimethylamine N-oxide electron transfer

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Transport reaction diagram

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: hydrogenase (acceptor)

Enzyme Commission Synonyms: H2 producing hydrogenase[ambiguous], hydrogen-lyase[ambiguous], hydrogenlyase[ambiguous], uptake hydrogenase[ambiguous], hydrogen:(acceptor) oxidoreductase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -44.452244Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Uses molecular hydrogen for the reduction of a variety of substances. Contains iron-sulfur clusters. The enzyme from some sources contains nickel.

Citations: [Adams80, Vignais01]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:29047

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Adams80: Adams MW, Mortenson LE, Chen JS (1980). "Hydrogenase." Biochim Biophys Acta 594(2-3);105-76. PMID: 6786341

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Vignais01: Vignais PM, Billoud B, Meyer J (2001). "Classification and phylogeny of hydrogenases." FEMS Microbiol Rev 25(4);455-501. PMID: 11524134

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Thu Nov 26, 2015, BIOCYC13B.