Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.12.99.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions Electron-Transfer-Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.12.99.6

Enzymes and Genes:
hydrogenase 2 Inferred from experiment : hybA , hybB , hybO , hybC ( Escherichia coli K-12 substr. MG1655 )
hydrogenase 1 Inferred from experiment : hyaA , hyaB , hyaC ( Escherichia coli K-12 substr. MG1655 )

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: hydrogenase (acceptor)

Enzyme Commission Synonyms: H2 producing hydrogenase[ambiguous], hydrogen-lyase[ambiguous], hydrogenlyase[ambiguous], uptake hydrogenase[ambiguous], hydrogen:(acceptor) oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -44.452244 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Uses molecular hydrogen for the reduction of a variety of substances. Contains iron-sulfur clusters. The enzyme from some sources contains nickel.

Citations: [Adams80, Vignais01]

Gene-Reaction Schematic: ?

Unification Links: Rhea:29047

Relationship Links: BRENDA:EC:1.12.99.6 , ENZYME:EC:1.12.99.6 , IUBMB-ExplorEnz:EC:1.12.99.6


References

Adams80: Adams MW, Mortenson LE, Chen JS (1980). "Hydrogenase." Biochim Biophys Acta 594(2-3);105-76. PMID: 6786341

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Vignais01: Vignais PM, Billoud B, Meyer J (2001). "Classification and phylogeny of hydrogenases." FEMS Microbiol Rev 25(4);455-501. PMID: 11524134


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, biocyc11.