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MetaCyc Reaction: 1.12.99.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions Electron-Transfer-Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.12.99.6

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : hydrogenase 1, oxygen tolerant hydrogenase Inferred from experiment : hyaC , hyaB , hyaA
hydrogenase 2 Inferred from experiment : hybA , hybB , hybO , hybC

In Pathway: hydrogen to fumarate electron transfer , hydrogen to dimethyl sulfoxide electron transfer , hydrogen to trimethylamine N-oxide electron transfer

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Transport reaction diagram

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: hydrogenase (acceptor)

Enzyme Commission Synonyms: H2 producing hydrogenase[ambiguous], hydrogen-lyase[ambiguous], hydrogenlyase[ambiguous], uptake hydrogenase[ambiguous], hydrogen:(acceptor) oxidoreductase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -44.452244 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Uses molecular hydrogen for the reduction of a variety of substances. Contains iron-sulfur clusters. The enzyme from some sources contains nickel.

Citations: [Adams80a, Vignais01]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:29047

Relationship Links: BRENDA:EC:1.12.99.6 , ENZYME:EC:1.12.99.6 , IUBMB-ExplorEnz:EC:1.12.99.6


References

Adams80a: Adams MW, Mortenson LE, Chen JS (1980). "Hydrogenase." Biochim Biophys Acta 594(2-3);105-76. PMID: 6786341

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Vignais01: Vignais PM, Billoud B, Meyer J (2001). "Classification and phylogeny of hydrogenases." FEMS Microbiol Rev 25(4);455-501. PMID: 11524134


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Sep 3, 2015, biocyc13.