MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Bacillus subtilis subtilis 168: 6-carboxy-5,6,7,8-tetrahydropterin synthaseInferred from experiment: queD
Escherichia coli K-12 substr. MG1655: 6-carboxy-5,6,7,8-tetrahydropterin synthaseInferred from experiment: queD

In Pathway: preQ0 biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 6-carboxytetrahydropterin synthase

Enzyme Commission Synonyms: CPH4 synthase, queD (gene name), ToyB, ykvK (gene name)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.5476685Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Binds Zn2+. Isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine. The enzyme from Escherichia coli can also convert 6-pyruvoyl tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin [McCarty09].

Citations: [Cicmil08]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R09959, Rhea:27966

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 24-Jan-2011 by Caspi R, SRI International


Cicmil08: Cicmil N, Shi L (2008). "Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis." Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 2);119-22. PMID: 18259064

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

McCarty09: McCarty RM, Somogyi A, Bandarian V (2009). "Escherichia coli QueD Is a 6-Carboxy-5,6,7,8-tetrahydropterin Synthase." Biochemistry 48(11);2301-3. PMID: 19231875

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun Nov 29, 2015, BIOCYC13B.