Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.3.5.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.3.5.3

Enzymes and Genes:
protoporphyrinogen oxidase Inferred from experiment : hemG ( Escherichia coli K-12 substr. MG1655 )

In Pathway: heme biosynthesis II (anaerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: protoporphyrinogen IX dehydrogenase (menaquinone)

Enzyme Commission Synonyms: HemG

Standard Gibbs Free Energy (ΔrG in kcal/mol): -150.27673 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments [Boynton09].

Gene-Reaction Schematic: ?

Unification Links: Rhea:27409

Relationship Links: BRENDA:EC:1.3.5.3 , ENZYME:EC:1.3.5.3 , IUBMB-ExplorEnz:EC:1.3.5.3

Credits:
Revised 14-Jun-2010 by Caspi R , SRI International


References

Boynton09: Boynton TO, Daugherty LE, Dailey TA, Dailey HA (2009). "Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity." Biochemistry 48(29):6705-11. PMID: 19583219

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13B.