|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Composite Reactions → Electron-Transfer-Reactions|
|Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Escherichia coli K-12 substr. MG1655 :||protoporphyrinogen oxidase
In Pathway: heme biosynthesis II (anaerobic)
Reaction Locations: inner membrane (sensu Gram-negative Bacteria)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: protoporphyrinogen IX dehydrogenase (menaquinone)
Enzyme Commission Synonyms: HemG
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 150.27673 [Latendresse13]
Enzyme Commission Summary:
This enzyme enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments [Boynton09].
Unification Links: Rhea:27409
Boynton09: Boynton TO, Daugherty LE, Dailey TA, Dailey HA (2009). "Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity." Biochemistry 48(29):6705-11. PMID: 19583219
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