MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite ReactionsElectron-Transfer-Reactions
Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: protoporphyrinogen oxidaseInferred from experiment: hemG

In Pathway: heme biosynthesis II (anaerobic), chlorophyllide a biosynthesis II (anaerobic)

Transport reaction diagram

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: protoporphyrinogen IX dehydrogenase (menaquinone)

Enzyme Commission Synonyms: HemG

Standard Gibbs Free Energy (ΔrG in kcal/mol): 150.27673Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments [Boynton09].

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:27409

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 14-Jun-2010 by Caspi R, SRI International


Boynton09: Boynton TO, Daugherty LE, Dailey TA, Dailey HA (2009). "Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity." Biochemistry 48(29):6705-11. PMID: 19583219

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun Nov 29, 2015, BIOCYC11A.