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MetaCyc Reaction: 3.1.13.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.13.1

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : polynucleotide phosphorylase Inferred from experiment : pnp
ribonuclease II Inferred from experiment : rnb

In Pathway: tRNA processing

Supersedes EC number: 3.1.4.20

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: exoribonuclease II

Enzyme Commission Synonyms: ribonuclease II, ribonuclease Q, BN ribonuclease, Escherichia coli exo-RNase II, RNase II, exoribonuclease (misleading), 5'-exoribonuclease (misleading)

Enzyme Commission Summary:
Preference for single-stranded RNA. The enzyme processes 3′-terminal extra-nucleotides of monomeric tRNA precursors, following the action of EC 3.1.26.5 ribonuclease P.

Citations: [Sporn69, Shimura78, Schmidt78, Nossal68]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:3.1.13.1 , ENZYME:EC:3.1.13.1 , IUBMB-ExplorEnz:EC:3.1.13.1

Credits:
Created 14-Jun-2010 by Shearer A , SRI International


References

Nossal68: Nossal NG, Singer MF (1968). "The processive degradation of individual polyribonucleotide chains. I. Escherichia coli ribonuclease II." J Biol Chem 243(5);913-22. PMID: 4867942

Schmidt78: Schmidt FJ, McClain WH (1978). "An Escherichia coli ribonuclease which removes an extra nucleotide from a biosynthetic intermediate of bacteriophage T4 proline transfer RNA." Nucleic Acids Res 5(11);4129-39. PMID: 364422

Shimura78: Shimura Y, Sakano H, Nagawa F (1978). "Specific ribonucleases involved in processing of tRNA precursors of Escherichia coli. Partial purification and some properties." Eur J Biochem 86(1);267-81. PMID: 350582

Sporn69: Sporn MB, Lazarus HM, Smith JM, Henderson WR (1969). "Studies on nuclear exoribonucleases. 3. Isolation and properties of the enzyme from normal and malignant tissues of the mouse." Biochemistry 8(4);1698-706. PMID: 5805304


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Apr 26, 2015, BIOCYC13A.