Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.1.2.-

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.2.-

In Pathway: actinorhodin biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: 3.1.2 -- Thiolester hydrolases

Summary:
ActIV catalyzes the formation of the second ring between C-5 and C-14 via an intramolecular aldol condensation [McDaniel94].

Citations: [Taguchi00a, FernandezMoreno94, Taguchi07, Ichinose99, Kanehisa05]


References

FernandezMoreno94: Fernandez-Moreno MA, Martinez E, Caballero JL, Ichinose K, Hopwood DA, Malpartida F (1994). "DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2)." J Biol Chem 269(40);24854-63. PMID: 7929165

Ichinose99: Ichinose K, Surti C, Taguchi T, Malpartida F, Booker-Milburn KI, Stephenson GR, Ebizuka Y, Hopwood DA (1999). "Proof that the ACTVI genetic region of Streptomyces coelicolor A3(2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin." Bioorg Med Chem Lett 9(3);395-400. PMID: 10091691

Kanehisa05: Kanehisa Laboratories (2005). "Biosynthesis of Type II Polyketide Backbone." KEGG: Kyoto Encyclopedia of Genes and Genomes. PMID: 16381885

McDaniel94: McDaniel, R., Ebert-Khosla, S., Hopwood, D.A., Khosla, C. (1994). "Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively." J. Am. Chem. Soc. 116(24): 10855-10859.

Taguchi00a: Taguchi T, Itou K, Ebizuka Y, Malpartida F, Hopwood DA, Surti CM, Booker-Milburn KI, Stephenson GR, Ichinose K (2000). "Chemical characterisation of disruptants of the Streptomyces coelicolor A3(2) actVI genes involved in actinorhodin biosynthesis." J Antibiot (Tokyo) 53(2);144-52. PMID: 10805574

Taguchi07: Taguchi, T., et al. (2007). "Possible Involvement of ActVI-ORFA in Transcriptional Regulation of actVI Tailoring-Step Genes for Actinorhodin Biosynthesis." FEMS Microbiol. Lett., Online Early.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc14.