MetaCyc Reaction: 3.1.2.-

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.1.2.-

In Pathway: actinorhodin biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3.1.2 -- Thiolester hydrolases

Standard Gibbs Free Energy (ΔrG in kcal/mol): 116.56534Inferred by computational analysis [Latendresse13]

ActIV catalyzes the formation of the second ring between C-5 and C-14 via an intramolecular aldol condensation [McDaniel94].

Citations: [Taguchi00, FernandezMoreno94, Taguchi07, Ichinose99, Kanehisa05]


FernandezMoreno94: Fernandez-Moreno MA, Martinez E, Caballero JL, Ichinose K, Hopwood DA, Malpartida F (1994). "DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2)." J Biol Chem 269(40);24854-63. PMID: 7929165

Ichinose99: Ichinose K, Surti C, Taguchi T, Malpartida F, Booker-Milburn KI, Stephenson GR, Ebizuka Y, Hopwood DA (1999). "Proof that the ACTVI genetic region of Streptomyces coelicolor A3(2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin." Bioorg Med Chem Lett 9(3);395-400. PMID: 10091691

Kanehisa05: Kanehisa Laboratories (2005). "Biosynthesis of Type II Polyketide Backbone." KEGG: Kyoto Encyclopedia of Genes and Genomes. PMID: 16381885

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

McDaniel94: McDaniel, R., Ebert-Khosla, S., Hopwood, D.A., Khosla, C. (1994). "Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively." J. Am. Chem. Soc. 116(24): 10855-10859.

Taguchi00: Taguchi T, Itou K, Ebizuka Y, Malpartida F, Hopwood DA, Surti CM, Booker-Milburn KI, Stephenson GR, Ichinose K (2000). "Chemical characterisation of disruptants of the Streptomyces coelicolor A3(2) actVI genes involved in actinorhodin biosynthesis." J Antibiot (Tokyo) 53(2);144-52. PMID: 10805574

Taguchi07: Taguchi, T., et al. (2007). "Possible Involvement of ActVI-ORFA in Transcriptional Regulation of actVI Tailoring-StepGenes for Actinorhodin Biosynthesis." FEMS Microbiol. Lett., Online Early.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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