MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: all-trans-phytoene synthase

Enzyme Commission Synonyms: prephytoene-diphosphate synthase (ambiguous), phytoene synthetase (ambiguous), PSase (ambiguous), geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous), 15-trans-phytoene synthase

Taxonomic Range: Bacteria

2 geranylgeranyl diphosphate → prephytoene diphosphate + diphosphate,
prephytoene diphosphate = all-trans-phytoene + diphosphate

Standard Gibbs Free Energy (ΔrG): -21.45996 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mn2+ for activity. The enzyme from the bacterium Pantoea agglomerans (previously known as Erwinia herbicola) produces the all-trans isomer of phytoene. cf. EC, 15-cis-phytoene synthase.

Citations: [IwataReuyl03a, Gregonis74]

Unification Links: KEGG:R07916, Rhea:32454

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 19-Apr-2012 by Caspi R, SRI International


Gregonis74: Gregonis DE, Rilling HC (1974). "The stereochemistry of trans-phytoene synthesis. Some observations on lycopersene as a carotene precursor and a mechanism for the synthesis of cis- and trans-phytoene." Biochemistry 13(7);1538-42. PMID: 4819767

IwataReuyl03a: Iwata-Reuyl D, Math SK, Desai SB, Poulter CD (2003). "Bacterial phytoene synthase: molecular cloning, expression, and characterization of Erwinia herbicola phytoene synthase." Biochemistry 42(11);3359-65. PMID: 12641468

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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