Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 5.5.1.18

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 5.5.1.18

Enzymes and Genes:
lycopene ε-cyclase Inferred from experiment : CrtL-e ( Solanum lycopersicum )
lycopene ε-cyclase Inferred from experiment : LCYe ( Lactuca sativa romaine )
lycopene ε cyclase Inferred from experiment : LUT2 ( Arabidopsis thaliana col )

In Pathway: δ-carotene biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: lycopene ε-cyclase

Enzyme Commission Synonyms: CrtL-e, LCYe

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.17 Inferred by computational analysis [Latendresse13]

Summary:
The enzyme catalyzes the following two reactions:

all-trans-lycopene = δ-carotene

δ-carotene → ε-carotene

In most organisms only δ-carotene is formed.

Enzyme Commission Summary:
The carotenoid all-trans-lycopene has the ψ-end group at both ends. When acting on one end, this enzyme forms δ-carotene. When acting on both ends it forms ε-carotene.

The enzyme catalyzes the following two reactions:

all-trans-lycopene = δ-carotene

δ-carotene → ε-carotene

Citations: [Cunningham01, Stickforth03]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R06963

Relationship Links: BRENDA:EC:5.5.1.18 , ENZYME:EC:5.5.1.18 , IUBMB-ExplorEnz:EC:5.5.1.18


References

Cunningham01: Cunningham FX, Gantt E (2001). "One ring or two? Determination of ring number in carotenoids by lycopene ε-cyclases." Proc Natl Acad Sci U S A 2001;98(5);2905-10. PMID: 11226339

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Stickforth03: Stickforth P, Steiger S, Hess WR, Sandmann G (2003). "A novel type of lycopene epsilon-cyclase in the marine cyanobacterium Prochlorococcus marinus MED4." Arch Microbiol 179(6);409-15. PMID: 12712234


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Dec 17, 2014, biocyc13.