MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: lycopene ε cyclaseInferred from experiment: LUT2
Lactuca sativa romaine: lycopene ε-cyclaseInferred from experiment: LCYe
Solanum lycopersicum: lycopene ε-cyclaseInferred from experiment: CrtL-e

In Pathway: δ-carotene biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: lycopene ε-cyclase

Enzyme Commission Synonyms: CrtL-e, LCYe

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.17Inferred by computational analysis [Latendresse13]

The enzyme catalyzes the following two reactions:

all-trans-lycopene = δ-carotene

δ-carotene → ε-carotene

In most organisms only δ-carotene is formed.

Enzyme Commission Summary:
The carotenoid all-trans-lycopene has the ψ-end group at both ends. When acting on one end, this enzyme forms δ-carotene. When acting on both ends it forms ε-carotene.

The enzyme catalyzes the following two reactions:

all-trans-lycopene = δ-carotene

δ-carotene → ε-carotene

Citations: [Cunningham01, Stickforth03]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R06963

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Cunningham01: Cunningham FX, Gantt E (2001). "One ring or two? Determination of ring number in carotenoids by lycopene ε-cyclases." Proc Natl Acad Sci U S A 2001;98(5);2905-10. PMID: 11226339

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Stickforth03: Stickforth P, Steiger S, Hess WR, Sandmann G (2003). "A novel type of lycopene epsilon-cyclase in the marine cyanobacterium Prochlorococcus marinus MED4." Arch Microbiol 179(6);409-15. PMID: 12712234

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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