MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:

Mycobacterium tuberculosis H37Rv: 2-trans-enoyl-ACP isomeraseInferred by computational analysis: echA10
2-trans-enoyl-ACP isomeraseInferred by computational analysis: echA11

In Pathway: mycolate biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: trans-2-decenoyl-[acyl-carrier protein] isomerase

Enzyme Commission Synonyms: β-hydroxydecanoyl thioester dehydrase, trans-2-cis-3-decenoyl-ACP isomerase, trans-2,cis-3-decenoyl-ACP isomerase, trans-2-decenoyl-ACP isomerase, FabM, decenoyl-[acyl-carrier-protein] δ2-trans3-cis-isomerase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.55Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleate and cis-vaccenate, in dissociated (or type II) fatty-acid biosynthesis.

Citations: [Marrakchi02, Brock67]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Brock67: Brock DJ, Kass LR, Bloch K (1967). "Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action." J Biol Chem 242(19);4432-40. PMID: 4863740

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Marrakchi02: Marrakchi H, Choi KH, Rock CO (2002). "A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae." J Biol Chem 277(47);44809-16. PMID: 12237320

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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