Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 5.3.3.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 5.3.3.14

Enzymes and Genes:
2-trans-enoyl-ACP isomerase Inferred by computational analysis : echA10 ( Mycobacterium tuberculosis H37Rv )
2-trans-enoyl-ACP isomerase Inferred by computational analysis : echA11 ( Mycobacterium tuberculosis H37Rv )

In Pathway: mycolate biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: trans-2-decenoyl-[acyl-carrier protein] isomerase

Enzyme Commission Synonyms: β-hydroxydecanoyl thioester dehydrase, trans-2-cis-3-decenoyl-ACP isomerase, trans-2,cis-3-decenoyl-ACP isomerase, trans-2-decenoyl-ACP isomerase, FabM, decenoyl-[acyl-carrier-protein] δ2-trans3-cis-isomerase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.55 Inferred by computational analysis [Latendresse, 2013]

Enzyme Commission Summary:
While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis.

Citations: [Marrakchi02b, Brock67]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:5.3.3.14 , ENZYME:EC:5.3.3.14 , IUBMB-ExplorEnz:EC:5.3.3.14


References

Brock67: Brock DJ, Kass LR, Bloch K (1967). "Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action." J Biol Chem 242(19);4432-40. PMID: 4863740

Latendresse, 2013: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Marrakchi02b: Marrakchi H, Choi KH, Rock CO (2002). "A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae." J Biol Chem 277(47);44809-16. PMID: 12237320


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC14B.