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MetaCyc Reaction: 1.1.1.M9

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number: 1.1.1.M9

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: 3-oxoacyl-[acyl-carrier-protein] reductase: fabG
Mycobacterium tuberculosis H37Rv: meromycolic acid 3-oxoacyl-[acyl-carrier-protein] reductase: fabG1

In Pathway: mycolate biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ ← a 3-oxoacyl-[acp] + NADPH + H+ (1.1.1.100/2.3.1.85/2.3.1.86)

Enzyme Commission Primary Name: meromycolic acid 3-oxoacyl-[acyl-carrier-protein] reductase

Standard Gibbs Free Energy (ΔrG): 20.375793 kcal/molInferred by computational analysis [Latendresse13]

Citations: [Marrakchi02a]

Gene-Reaction Schematic

Gene-Reaction Schematic


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Marrakchi02a: Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard A (2002). "MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II." Microbiology 148(Pt 4);951-60. PMID: 11932442


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 20.0 (software by SRI International) on Thu May 5, 2016, BIOCYC12.