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MetaCyc Reaction: 1.2.1.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.3

Enzymes and Genes:

Antirrhinum majus : benzaldehyde dehydrogenase Inferred from experiment : BALDH
Corynebacterium glutamicum ATCC 13032 : acetaldehyde dehydrogenase Inferred from experiment : ald
Homo sapiens :
Paracoccus denitrificans PD1222 : aldehyde dehydrogenase (NAD+) Inferred from experiment : adh
Pseudomonas oleovorans : aldehyde dehydrogenase : alkH
Saccharomyces cerevisiae :

In Pathway: ethanol degradation II , oxidative ethanol degradation III , ethanol degradation IV , hypotaurine degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (NAD+)

Enzyme Commission Synonyms: CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, aldehyde dehydrogenase (NAD)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -15.27533 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.

Citations: [Racker49]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (1.2.1.3):
i1: acetaldehyde + NAD+ + H2O → acetate + NADH + 2 H+ (1.2.1.3)

Unification Links: KEGG:R00710 , Rhea:25295

Relationship Links: BRENDA:EC:1.2.1.3 , ENZYME:EC:1.2.1.3 , IUBMB-ExplorEnz:EC:1.2.1.3


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Racker49: Racker, E. (1949). "Aldehyde dehydrogenase, a diphosphopyridine nucleotide-linked enzyme." J Biol Chem 177(2);883-92. PMID: 18110463


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Sep 1, 2015, biocyc11.