MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Antirrhinum majus: benzaldehyde dehydrogenaseInferred from experiment: BALDH
Corynebacterium glutamicum ATCC 13032: acetaldehyde dehydrogenaseInferred from experiment: ald
Homo sapiens:
Paracoccus denitrificans PD1222: aldehyde dehydrogenase (NAD+)Inferred from experiment: adh
Pseudomonas oleovorans: aldehyde dehydrogenase: alkH
Saccharomyces cerevisiae:

In Pathway: ethanol degradation II, oxidative ethanol degradation III, ethanol degradation IV, hypotaurine degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (NAD+)

Enzyme Commission Synonyms: CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, aldehyde dehydrogenase (NAD)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -15.27533Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.

Citations: [Racker49]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (
i1: acetaldehyde + NAD+ + H2O → acetate + NADH + 2 H+ (

Unification Links: KEGG:R00710, Rhea:25295

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Racker49: Racker, E. (1949). "Aldehyde dehydrogenase, a diphosphopyridine nucleotide-linked enzyme." J Biol Chem 177(2);883-92. PMID: 18110463

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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