Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.2.1.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.3

Enzymes and Genes:
aldehyde dehydrogenase (NAD+) Inferred from experiment : adh ( Paracoccus denitrificans PD1222 )
benzaldehyde dehydrogenase Inferred from experiment : BALDH ( Antirrhinum majus )
aldehyde dehydrogenase : alkH ( Pseudomonas oleovorans )
mitochondrial aldehyde dehydrogenase Inferred from experiment : ALDH2 ( Homo sapiens )
aldehyde dehydrogenase, mitochondrial : ALD5 ( Saccharomyces cerevisiae )
potassium-activated aldehyde dehydrogenase, mitochondrial : ALD4 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase : ALD2 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase : ALD3 ( Saccharomyces cerevisiae )
fatty aldehyde dehydrogenase : ALDH3A2 ( Homo sapiens )
4-trimethylaminobutyraldehyde dehydrogenase : ALDH9A1 ( Homo sapiens )

In Pathway: ethanol degradation II , oxidative ethanol degradation III , ethanol degradation IV , hypotaurine degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (NAD+)

Enzyme Commission Synonyms: CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, aldehyde dehydrogenase (NAD)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -15.27533 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.

Citations: [Racker49]

Gene-Reaction Schematic: ?

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (1.2.1.3):
i1: acetaldehyde + NAD+ + H2O → acetate + NADH + 2 H+ (1.2.1.3)

Unification Links: KEGG:R00710 , Rhea:25295

Relationship Links: BRENDA:EC:1.2.1.3 , ENZYME:EC:1.2.1.3 , IUBMB-ExplorEnz:EC:1.2.1.3


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Racker49: Racker, E. (1949). "Aldehyde dehydrogenase, a diphosphopyridine nucleotide-linked enzyme." J Biol Chem 177(2);883-92. PMID: 18110463


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, biocyc14.