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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: methionine adenosyltransferaseInferred from experiment: SAM-1
Bacillus subtilis: S-adenosylmethionine synthetaseInferred from experiment: metK
Catharanthus roseus: S-adenosylmethionine synthetaseInferred from experiment: SAMS1
Escherichia coli K-12 substr. MG1655: methionine adenosyltransferaseInferred from experiment: metK
Oryza: S-adenosyl-L-methionine synthetaseInferred from experiment: pOS-SAMS2
Rattus norvegicus: methionine adenosyltransferaseInferred from experiment: Mat1a
Saccharomyces cerevisiae: methionine adenosyltransferase 1Inferred from experiment: sam1
methionine adenosyltransferase 2Inferred from experiment: sam2

In Pathway: S-adenosyl-L-methionine cycle II, 2'-deoxymugineic acid phytosiderophore biosynthesis, L-methionine degradation I (to L-homocysteine), ethylene biosynthesis I (plants), S-adenosyl-L-methionine biosynthesis

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: methionine adenosyltransferase

Enzyme Commission Synonyms: adenosylmethionine synthetase, ATP-methionine adenosyltransferase, methionine S-adenosyltransferase, methionine-activating enzyme, S-adenosyl-L-methionine synthetase, S-adenosylmethionine synthase, S-adenosylmethionine synthetase, AdoMet synthetase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -49.60785Inferred by computational analysis [Latendresse13]

Citations: [CANTONI57, CATONI53, MUDD58]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00177, Rhea:21080

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O22350, UniProt:RELATED-TO:O50163, UniProt:RELATED-TO:O60198, UniProt:RELATED-TO:P0A817, UniProt:RELATED-TO:P10659, UniProt:RELATED-TO:P13444, UniProt:RELATED-TO:P17562, UniProt:RELATED-TO:P18298, UniProt:RELATED-TO:P19358, UniProt:RELATED-TO:P23686, UniProt:RELATED-TO:P24260, UniProt:RELATED-TO:P31153, UniProt:RELATED-TO:P40320, UniProt:RELATED-TO:P43280, UniProt:RELATED-TO:P43281, UniProt:RELATED-TO:P43282, UniProt:RELATED-TO:P43762, UniProt:RELATED-TO:P48466, UniProt:RELATED-TO:P48498, UniProt:RELATED-TO:P49612, UniProt:RELATED-TO:P49613, UniProt:RELATED-TO:P50299, UniProt:RELATED-TO:P54419, UniProt:RELATED-TO:P56460, UniProt:RELATED-TO:P78003, UniProt:RELATED-TO:Q7M4Y8, UniProt:RELATED-TO:Q91X83, UniProt:RELATED-TO:Q00266, UniProt:RELATED-TO:Q12642, UniProt:RELATED-TO:Q39465, UniProt:RELATED-TO:Q49070, UniProt:RELATED-TO:Q90862, UniProt:RELATED-TO:Q9CEE0, UniProt:RELATED-TO:Q9JVV6, UniProt:RELATED-TO:Q9PNJ8, UniProt:RELATED-TO:Q9S992


CANTONI57: CANTONI GL, DURELL J (1957). "Activation of methionine for transmethylation. II. The methionine-activating enzyme; studies on the mechanism of the reaction." J Biol Chem 225(2);1033-48. PMID: 13416303

CATONI53: CATONI GL (1953). "S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate." J Biol Chem 204(1);403-16. PMID: 13084611

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MUDD58: MUDD SH, CANTONI GL (1958). "Activation of methionine for transmethylation. III. The methionine-activating enzyme of Bakers' yeast." J Biol Chem 231(1);481-92. PMID: 13538985

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun Feb 14, 2016, biocyc14.