Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 2.5.1.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.5.1.6

Enzymes and Genes:
methionine adenosyltransferase Inferred from experiment : metK ( Escherichia coli K-12 substr. MG1655 )
S-adenosylmethionine synthetase Inferred from experiment : metK ( Bacillus subtilis )
S-adenosyl-L-methionine synthetase Inferred from experiment : pOS-SAMS2 ( Oryza )
S-adenosylmethionine synthetase Inferred from experiment : SAMS1 ( Catharanthus roseus )
methionine adenosyltransferase Inferred from experiment : Mat1a ( Rattus norvegicus )
methionine adenosyltransferase Inferred from experiment : SAM-1 ( Arabidopsis thaliana col )
methionine adenosyltransferase 2 Inferred from experiment : sam2 ( Saccharomyces cerevisiae )
methionine adenosyltransferase 1 Inferred from experiment : sam1 ( Saccharomyces cerevisiae )

In Pathway: S-adenosyl-L-methionine cycle II , 2'-deoxymugineic acid phytosiderophore biosynthesis , methionine degradation I (to homocysteine) , ethylene biosynthesis I (plants) , S-adenosyl-L-methionine biosynthesis

Supersedes EC number: 2.4.2.13

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: methionine adenosyltransferase

Enzyme Commission Synonyms: adenosylmethionine synθse, ATP-methionine adenosyltransferase, methionine S-adenosyltransferase, methionine-activating enzyme, S-adenosyl-L-methionine synθse, S-adenosylmethionine synthase, S-adenosylmethionine synθse, AdoMet synθse

Standard Gibbs Free Energy (ΔrG in kcal/mol): -49.60785 Inferred by computational analysis [Latendresse13]

Citations: [CANTONI57, CATONI53, MUDD58]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00177 , Rhea:21080

Relationship Links: BRENDA:EC:2.5.1.6 , ENZYME:EC:2.5.1.6 , IUBMB-ExplorEnz:EC:2.5.1.6 , UniProt:RELATED-TO:O22350 , UniProt:RELATED-TO:O50163 , UniProt:RELATED-TO:O60198 , UniProt:RELATED-TO:P0A817 , UniProt:RELATED-TO:P10659 , UniProt:RELATED-TO:P13444 , UniProt:RELATED-TO:P17562 , UniProt:RELATED-TO:P18298 , UniProt:RELATED-TO:P19358 , UniProt:RELATED-TO:P23686 , UniProt:RELATED-TO:P24260 , UniProt:RELATED-TO:P31153 , UniProt:RELATED-TO:P40320 , UniProt:RELATED-TO:P43280 , UniProt:RELATED-TO:P43281 , UniProt:RELATED-TO:P43282 , UniProt:RELATED-TO:P43762 , UniProt:RELATED-TO:P48466 , UniProt:RELATED-TO:P48498 , UniProt:RELATED-TO:P49612 , UniProt:RELATED-TO:P49613 , UniProt:RELATED-TO:P50299 , UniProt:RELATED-TO:P54419 , UniProt:RELATED-TO:P56460 , UniProt:RELATED-TO:P78003 , UniProt:RELATED-TO:Q7M4Y8 , UniProt:RELATED-TO:Q91X83 , UniProt:RELATED-TO:Q00266 , UniProt:RELATED-TO:Q12642 , UniProt:RELATED-TO:Q39465 , UniProt:RELATED-TO:Q49070 , UniProt:RELATED-TO:Q90862 , UniProt:RELATED-TO:Q9CEE0 , UniProt:RELATED-TO:Q9JVV6 , UniProt:RELATED-TO:Q9PNJ8 , UniProt:RELATED-TO:Q9S992


References

CANTONI57: CANTONI GL, DURELL J (1957). "Activation of methionine for transmethylation. II. The methionine-activating enzyme; studies on the mechanism of the reaction." J Biol Chem 225(2);1033-48. PMID: 13416303

CATONI53: CATONI GL (1953). "S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate." J Biol Chem 204(1);403-16. PMID: 13084611

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MUDD58: MUDD SH, CANTONI GL (1958). "Activation of methionine for transmethylation. III. The methionine-activating enzyme of Bakers' yeast." J Biol Chem 231(1);481-92. PMID: 13538985


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc14.