MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col : methionine adenosyltransferase Inferred from experiment : SAM-1
Bacillus subtilis : S-adenosylmethionine synthetase Inferred from experiment : metK
Catharanthus roseus : S-adenosylmethionine synthetase Inferred from experiment : SAMS1
Escherichia coli K-12 substr. MG1655 : methionine adenosyltransferase Inferred from experiment : metK
Oryza : S-adenosyl-L-methionine synthetase Inferred from experiment : pOS-SAMS2
Rattus norvegicus : methionine adenosyltransferase Inferred from experiment : Mat1a
Saccharomyces cerevisiae : methionine adenosyltransferase 1 Inferred from experiment : sam1
methionine adenosyltransferase 2 Inferred from experiment : sam2

In Pathway: S-adenosyl-L-methionine cycle II , 2'-deoxymugineic acid phytosiderophore biosynthesis , L-methionine degradation I (to L-homocysteine) , ethylene biosynthesis I (plants) , S-adenosyl-L-methionine biosynthesis

Supersedes EC number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: methionine adenosyltransferase

Enzyme Commission Synonyms: adenosylmethionine synthetase, ATP-methionine adenosyltransferase, methionine S-adenosyltransferase, methionine-activating enzyme, S-adenosyl-L-methionine synthetase, S-adenosylmethionine synthase, S-adenosylmethionine synthetase, AdoMet synthetase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -49.60785 Inferred by computational analysis [Latendresse13]

Citations: [CANTONI57, CATONI53, MUDD58]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R00177 , Rhea:21080

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O22350 , UniProt:RELATED-TO:O50163 , UniProt:RELATED-TO:O60198 , UniProt:RELATED-TO:P0A817 , UniProt:RELATED-TO:P10659 , UniProt:RELATED-TO:P13444 , UniProt:RELATED-TO:P17562 , UniProt:RELATED-TO:P18298 , UniProt:RELATED-TO:P19358 , UniProt:RELATED-TO:P23686 , UniProt:RELATED-TO:P24260 , UniProt:RELATED-TO:P31153 , UniProt:RELATED-TO:P40320 , UniProt:RELATED-TO:P43280 , UniProt:RELATED-TO:P43281 , UniProt:RELATED-TO:P43282 , UniProt:RELATED-TO:P43762 , UniProt:RELATED-TO:P48466 , UniProt:RELATED-TO:P48498 , UniProt:RELATED-TO:P49612 , UniProt:RELATED-TO:P49613 , UniProt:RELATED-TO:P50299 , UniProt:RELATED-TO:P54419 , UniProt:RELATED-TO:P56460 , UniProt:RELATED-TO:P78003 , UniProt:RELATED-TO:Q7M4Y8 , UniProt:RELATED-TO:Q91X83 , UniProt:RELATED-TO:Q00266 , UniProt:RELATED-TO:Q12642 , UniProt:RELATED-TO:Q39465 , UniProt:RELATED-TO:Q49070 , UniProt:RELATED-TO:Q90862 , UniProt:RELATED-TO:Q9CEE0 , UniProt:RELATED-TO:Q9JVV6 , UniProt:RELATED-TO:Q9PNJ8 , UniProt:RELATED-TO:Q9S992


CANTONI57: CANTONI GL, DURELL J (1957). "Activation of methionine for transmethylation. II. The methionine-activating enzyme; studies on the mechanism of the reaction." J Biol Chem 225(2);1033-48. PMID: 13416303

CATONI53: CATONI GL (1953). "S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate." J Biol Chem 204(1);403-16. PMID: 13084611

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MUDD58: MUDD SH, CANTONI GL (1958). "Activation of methionine for transmethylation. III. The methionine-activating enzyme of Bakers' yeast." J Biol Chem 231(1);481-92. PMID: 13538985

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, biocyc13.