|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Homo sapiens :||hormone-sensitive lipase
|Saccharomyces cerevisiae :||steryl ester hydrolase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: sterol esterase
Enzyme Commission Synonyms: cholesterol esterase, cholesteryl ester synthase, triterpenol esterase, cholesteryl esterase, cholesteryl ester hydrolase, sterol ester hydrolase, cholesterol ester hydrolase, cholesterase, acylcholesterol lipase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -13.038246 [Latendresse13]
Enzyme Commission Summary:
A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts.
Instance reaction of [a phosphatidylcholine + H2O → a 1-acyl 2-lyso-phosphatidylcholine + a long-chain fatty acid + H+] (126.96.36.199):
i5: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (188.8.131.52)
Instance reaction of [an acyl-CoA + a 1-acyl 2-lyso-phosphatidylcholine ↔ a phosphatidylcholine + coenzyme A] (184.108.40.206):
i3: palmitoyl-CoA + 1-16:0-2-lysophosphatidylcholine ↔ 1,2-dipalmitoyl-phosphatidylcholine + coenzyme A (220.127.116.11)
Instance reaction of [a triglyceride + H2O → a 1,2-diglyceride + a fatty acid + H+] (18.104.22.168):
i4: tributyrin + H2O → 1,2-dibutyrin + butanoate + H+ (22.214.171.124)
Instance reaction of [an L-1-phosphatidylethanolamine[periplasmic space] + H2O[periplasmic space] → a fatty acid[periplasmic space] + a 1-acyl 2-lyso-phosphatidylethanolamine[periplasmic space] + H+[periplasmic space]] (126.96.36.199):
i2: 1-18:1-2-18:1-phosphatidylethanolamine + H2O → 1-18:1-lysophosphatidylethanolamine + oleate + H+ (188.8.131.52)
Instance reactions of [a steryl-ester + H2O → a fatty acid + a sterol + H+] (184.108.40.206):
i7: ergosteryl oleate + H2O → ergosterol + oleate + H+ (220.127.116.11)
i8: lanosteryl oleate + H2O → lanosterol + oleate + H+ (18.104.22.168)
Unification Links: KEGG:R02115
Relationship Links: BRENDA:EC:22.214.171.124 , ENZYME:EC:126.96.36.199 , IUBMB-ExplorEnz:EC:188.8.131.52 , UniProt:RELATED-TO:P07882 , UniProt:RELATED-TO:P30122 , UniProt:RELATED-TO:P38571 , UniProt:RELATED-TO:Q64285 , UniProt:RELATED-TO:Q64571
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