Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
twitter

MetaCyc Reaction: 3.1.1.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.1.3

Enzymes and Genes:

Arabidopsis thaliana col : triacylglycerol lipase Inferred from experiment : SDP1
Homo sapiens : hormone-sensitive lipase Inferred from experiment : LIPE
pancreatic triacylglycerol lipase Inferred from experiment : PNLIP
Saccharomyces cerevisiae : triacylglycerol lipase Inferred from experiment : TGL4
triacylglycerol lipase Inferred from experiment : TGL5
triacylglycerol lipase Inferred from experiment : TGL3
steryl ester hydrolase : TGL1

In Pathway: triacylglycerol degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
tributyrin + H2O → 1,2-dibutyrin + butanoate + H+ (3.1.1.3)

Enzyme Commission Primary Name: triacylglycerol lipase

Enzyme Commission Synonyms: lipase (ambiguous), butyrinase, tributyrinase, Tween hydrolase, steapsin, triacetinase, tributyrin esterase, Tweenase, amno N-AP, Takedo 1969-4-9, Meito MY 30, Tweenesterase, GA 56, capalase L, triglyceride hydrolase, triolein hydrolase, tween-hydrolyzing esterase, amano CE, cacordase, triglyceridase, triacylglycerol ester hydrolase, amano P, amano AP, PPL, glycerol-ester hydrolase, GEH, meito Sangyo OF lipase, hepatic lipase, lipazin, post-heparin plasma protamine-resistant lipase, salt-resistant post-heparin lipase, heparin releasable hepatic lipase, amano CES, amano B, tributyrase, triglyceride lipase, liver lipase, hepatic monoacylglycerol acyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.038254 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolysed.

Citations: [Korn57, Lynn60, Sarda58]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a phosphatidylcholine + H2O → a 1-acyl 2-lyso-phosphatidylcholine + a long-chain fatty acid + H+] (3.1.1.4):
i5: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (3.1.1.4)

Instance reaction of [an acyl-CoA + a 1-acyl 2-lyso-phosphatidylcholine ↔ a phosphatidylcholine + coenzyme A] (2.3.1.23):
i3: palmitoyl-CoA + 1-16:0-2-lysophosphatidylcholine ↔ 1,2-dipalmitoyl-phosphatidylcholine + coenzyme A (2.3.1.23)

Instance reaction of [an L-1-phosphatidylethanolamine[periplasmic space] + H2O[periplasmic space] → a fatty acid[periplasmic space] + a 1-acyl 2-lyso-phosphatidylethanolamine[periplasmic space] + H+[periplasmic space]] (3.1.1.4):
i2: 1-18:1-2-18:1-phosphatidylethanolamine + H2O → 1-18:1-lysophosphatidylethanolamine + oleate + H+ (3.1.1.4)

Instance reactions of [a steryl-ester + H2O → a fatty acid + a sterol + H+] (3.1.1.13):
i7: ergosteryl oleate + H2O → ergosterol + oleate + H+ (3.1.1.13)

i8: lanosteryl oleate + H2O → lanosterol + oleate + H+ (3.1.1.13)

Instance reaction of [a triglyceride + H2O → a 1,2-diglyceride + a fatty acid + H+] (3.1.1.3):
i4: tributyrin + H2O → 1,2-dibutyrin + butanoate + H+ (3.1.1.3)

Unification Links: KEGG:R01369

Relationship Links: BRENDA:EC:3.1.1.3 , ENZYME:EC:3.1.1.3 , IUBMB-ExplorEnz:EC:3.1.1.3 , UniProt:RELATED-TO:O66015 , UniProt:RELATED-TO:P04634 , UniProt:RELATED-TO:P06857 , UniProt:RELATED-TO:P07098 , UniProt:RELATED-TO:P07867 , UniProt:RELATED-TO:P08658 , UniProt:RELATED-TO:P0C0R3 , UniProt:RELATED-TO:P10335 , UniProt:RELATED-TO:P11150 , UniProt:RELATED-TO:P16233 , UniProt:RELATED-TO:P16386 , UniProt:RELATED-TO:P17573 , UniProt:RELATED-TO:P17892 , UniProt:RELATED-TO:P20261 , UniProt:RELATED-TO:P22394 , UniProt:RELATED-TO:P24484 , UniProt:RELATED-TO:P24640 , UniProt:RELATED-TO:P26504 , UniProt:RELATED-TO:P26876 , UniProt:RELATED-TO:P29183 , UniProt:RELATED-TO:P29605 , UniProt:RELATED-TO:P32946 , UniProt:RELATED-TO:P32947 , UniProt:RELATED-TO:P32948 , UniProt:RELATED-TO:P32949 , UniProt:RELATED-TO:P34163 , UniProt:RELATED-TO:P40601 , UniProt:RELATED-TO:P41365 , UniProt:RELATED-TO:P50903 , UniProt:RELATED-TO:P54316 , UniProt:RELATED-TO:P61871 , UniProt:RELATED-TO:P61872 , UniProt:RELATED-TO:P75268 , UniProt:RELATED-TO:P78898 , UniProt:RELATED-TO:P81139 , UniProt:RELATED-TO:Q8VC44 , UniProt:RELATED-TO:Q9TSB3 , UniProt:RELATED-TO:Q9UP41 , UniProt:RELATED-TO:Q02104 , UniProt:RELATED-TO:Q02351 , UniProt:RELATED-TO:Q05489 , UniProt:RELATED-TO:Q12614 , UniProt:RELATED-TO:Q12616 , UniProt:RELATED-TO:Q28681 , UniProt:RELATED-TO:Q29458 , UniProt:RELATED-TO:Q48992 , UniProt:RELATED-TO:Q59537 , UniProt:RELATED-TO:Q59538 , UniProt:RELATED-TO:Q59539 , UniProt:RELATED-TO:Q59811 , UniProt:RELATED-TO:Q59932 , UniProt:RELATED-TO:Q64425


References

Korn57: Korn ED, Quigley TW (1957). "Lipoprotein lipase of chicken adipose tissue." J Biol Chem 226(2);833-9. PMID: 13438870

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lynn60: Lynn WS, Perryman NC (1960). "Properties and purification of adipose tissue lipase." J Biol Chem 235;1912-6. PMID: 14419169

Sarda58: Sarda L, Desnuelle P (1958). "[Actions of pancreatic lipase on esters in emulsions.]." Biochim Biophys Acta 30(3);513-21. PMID: 13618257


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Aug 29, 2015, biocyc13.