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discounted EARLY registration ends Dec 31, 2014
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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.1.1.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.1.3

Enzymes and Genes:
steryl ester hydrolase : TGL1 ( Saccharomyces cerevisiae )
triacylglycerol lipase Inferred from experiment : TGL3 ( Saccharomyces cerevisiae )
triacylglycerol lipase Inferred from experiment : TGL5 ( Saccharomyces cerevisiae )
triacylglycerol lipase Inferred from experiment : TGL4 ( Saccharomyces cerevisiae )
pancreatic triacylglycerol lipase Inferred from experiment : PNLIP ( Homo sapiens )
hormone-sensitive lipase Inferred from experiment : LIPE ( Homo sapiens )
triacylglycerol lipase Inferred from experiment : SDP1 ( Arabidopsis thaliana col )

In Pathway: triacylglycerol degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
tributyrin + H2O → 1,2-dibutyrin + butanoate + H+ (3.1.1.3)

Enzyme Commission Primary Name: triacylglycerol lipase

Enzyme Commission Synonyms: lipase (ambiguous), butyrinase, tributyrinase, Tween hydrolase, steapsin, triacetinase, tributyrin esterase, Tweenase, amno N-AP, Takedo 1969-4-9, Meito MY 30, Tweenesterase, GA 56, capalase L, triglyceride hydrolase, triolein hydrolase, tween-hydrolyzing esterase, amano CE, cacordase, triglyceridase, triacylglycerol ester hydrolase, amano P, amano AP, PPL, glycerol-ester hydrolase, GEH, meito Sangyo OF lipase, hepatic lipase, lipazin, post-heparin plasma protamine-resistant lipase, salt-resistant post-heparin lipase, heparin releasable hepatic lipase, amano CES, amano B, tributyrase, triglyceride lipase, liver lipase, hepatic monoacylglycerol acyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.038254 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolysed.

Citations: [Korn57, Lynn60, Sarda58]

Gene-Reaction Schematic: ?

Instance reaction of [an acyl-CoA + a 2-lyso-phosphatidylcholine ↔ a phosphatidylcholine + coenzyme A] (2.3.1.23):
i4: 1-16:0-2-lysophosphatidylcholine + palmitoyl-CoA ↔ 1,2-dipalmitoyl-phosphatidylcholine + coenzyme A (2.3.1.23)

Instance reaction of [an L-1-phosphatidyl-ethanolamine[periplasmic space] + H2O[periplasmic space] → a fatty acid[periplasmic space] + a 2-lyso-phosphatidyl-ethanolamine[periplasmic space] + H+[periplasmic space]] (3.1.1.4):
i3: 1-18:1-2-18:1-phosphatidylethanolamine + H2O → 1-18:1-lysophosphatidylethanolamine + oleate + H+ (3.1.1.4)

Instance reaction of [a phosphatidylcholine + H2O → a 2-lyso-phosphatidylcholine + a fatty acid + H+] (3.1.1.4):
i6: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (3.1.1.4)

Instance reaction of [a triglyceride + H2O → a 1,2-diglyceride + a fatty acid + H+] (3.1.1.3):
i5: tributyrin + H2O → 1,2-dibutyrin + butanoate + H+ (3.1.1.3)

Instance reaction of [a steryl-ester + H2O → a fatty acid + a sterol + H+] (3.1.1.13):
i7: lanosteryl oleate + H2O → lanosterol + oleate + H+ (3.1.1.13)

Unification Links: KEGG:R01369

Relationship Links: BRENDA:EC:3.1.1.3 , ENZYME:EC:3.1.1.3 , IUBMB-ExplorEnz:EC:3.1.1.3 , UniProt:RELATED-TO:O66015 , UniProt:RELATED-TO:P04634 , UniProt:RELATED-TO:P06857 , UniProt:RELATED-TO:P07098 , UniProt:RELATED-TO:P07867 , UniProt:RELATED-TO:P08658 , UniProt:RELATED-TO:P0C0R3 , UniProt:RELATED-TO:P10335 , UniProt:RELATED-TO:P11150 , UniProt:RELATED-TO:P16233 , UniProt:RELATED-TO:P16386 , UniProt:RELATED-TO:P17573 , UniProt:RELATED-TO:P17892 , UniProt:RELATED-TO:P20261 , UniProt:RELATED-TO:P22394 , UniProt:RELATED-TO:P24484 , UniProt:RELATED-TO:P24640 , UniProt:RELATED-TO:P26504 , UniProt:RELATED-TO:P26876 , UniProt:RELATED-TO:P29183 , UniProt:RELATED-TO:P29605 , UniProt:RELATED-TO:P32946 , UniProt:RELATED-TO:P32947 , UniProt:RELATED-TO:P32948 , UniProt:RELATED-TO:P32949 , UniProt:RELATED-TO:P34163 , UniProt:RELATED-TO:P40601 , UniProt:RELATED-TO:P41365 , UniProt:RELATED-TO:P50903 , UniProt:RELATED-TO:P54316 , UniProt:RELATED-TO:P61871 , UniProt:RELATED-TO:P61872 , UniProt:RELATED-TO:P75268 , UniProt:RELATED-TO:P78898 , UniProt:RELATED-TO:P81139 , UniProt:RELATED-TO:Q8VC44 , UniProt:RELATED-TO:Q9TSB3 , UniProt:RELATED-TO:Q9UP41 , UniProt:RELATED-TO:Q02104 , UniProt:RELATED-TO:Q02351 , UniProt:RELATED-TO:Q05489 , UniProt:RELATED-TO:Q12614 , UniProt:RELATED-TO:Q12616 , UniProt:RELATED-TO:Q28681 , UniProt:RELATED-TO:Q29458 , UniProt:RELATED-TO:Q48992 , UniProt:RELATED-TO:Q59537 , UniProt:RELATED-TO:Q59538 , UniProt:RELATED-TO:Q59539 , UniProt:RELATED-TO:Q59811 , UniProt:RELATED-TO:Q59932 , UniProt:RELATED-TO:Q64425


References

Korn57: Korn ED, Quigley TW (1957). "Lipoprotein lipase of chicken adipose tissue." J Biol Chem 226(2);833-9. PMID: 13438870

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lynn60: Lynn WS, Perryman NC (1960). "Properties and purification of adipose tissue lipase." J Biol Chem 235;1912-6. PMID: 14419169

Sarda58: Sarda L, Desnuelle P (1958). "[Actions of pancreatic lipase on esters in emulsions.]." Biochim Biophys Acta 30(3);513-21. PMID: 13618257


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC14A.