MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateMacromolecule ReactionsPolynucleotide-ReactionsRNA-ReactionstRNA-Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: tRNA C32 thiolaseInferred from experiment: ttcA
ThiIInferred from experiment: thiI

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: tRNA sulfurtransferase

Enzyme Commission Synonyms: transfer ribonucleate sulfurtransferase, RNA sulfurtransferase, ribonucleate sulfurtransferase, transfer RNA sulfurtransferase, transfer RNA thiolase

Taxonomic Range: Archaea, Bacteria

Enzyme Commission Summary:
A group of enzymes transferring sulfur to various nucleotides in a tRNA chain, producing residues such as 4-thiouridylate. With some enzymes mercaptopyruvate can act as sulfur donor.

Citations: [Abrell71, Hayward66, Lipsett66, Wong70]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Abrell71: Abrell JW, Kaufman EE, Lipsett MN (1971). "The biosynthesis of 4-thiouridylate. Separation and purification of two enzymes in the transfer ribonucleic acid-sulfurtransferase system." J Biol Chem 246(2);294-301. PMID: 5541999

Hayward66: Hayward RS, Weiss SB (1966). "RNA thiolase: the enzymatic transfer of sulfur from cysteine to sRNA in Escherichia coli extracts." Proc Natl Acad Sci U S A 55(5);1161-8. PMID: 5334200

Lipsett66: Lipsett MN, Peterkofsky A (1966). "Enzymatic thiolation of E. coli sRNA." Proc Natl Acad Sci U S A 55(5);1169-74. PMID: 5334201

Wong70: Wong TW, Weiss SB, Eliceiri GL, Bryant J (1970). "Ribonucleic acid sulfurtransferase from Bacillus subtilis W168. Sulfuration with beta-mercaptopyruvate and properties of the enzyme system." Biochemistry 9(11);2376-86. PMID: 4987417

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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