Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.8.1.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions tRNA-Reactions

EC Number: 2.8.1.4

Enzymes and Genes:
ThiI Inferred from experiment : thiI ( Escherichia coli K-12 substr. MG1655 )
tRNA C32 thiolase Inferred from experiment : ttcA ( Escherichia coli K-12 substr. MG1655 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: tRNA sulfurtransferase

Enzyme Commission Synonyms: transfer ribonucleate sulfurtransferase, RNA sulfurtransferase, ribonucleate sulfurtransferase, transfer RNA sulfurtransferase, transfer RNA thiolase

Enzyme Commission Summary:
A group of enzymes transferring sulfur to various nucleotides in a tRNA chain, producing residues such as 4-thiouridylate. With some enzymes mercaptopyruvate can act as sulfur donor.

Citations: [Abrell71, Hayward66, Lipsett66, Wong70]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.8.1.4 , ENZYME:EC:2.8.1.4 , IUBMB-ExplorEnz:EC:2.8.1.4


References

Abrell71: Abrell JW, Kaufman EE, Lipsett MN (1971). "The biosynthesis of 4-thiouridylate. Separation and purification of two enzymes in the transfer ribonucleic acid-sulfurtransferase system." J Biol Chem 246(2);294-301. PMID: 5541999

Hayward66: Hayward RS, Weiss SB (1966). "RNA thiolase: the enzymatic transfer of sulfur from cysteine to sRNA in Escherichia coli extracts." Proc Natl Acad Sci U S A 55(5);1161-8. PMID: 5334200

Lipsett66: Lipsett MN, Peterkofsky A (1966). "Enzymatic thiolation of E. coli sRNA." Proc Natl Acad Sci U S A 55(5);1169-74. PMID: 5334201

Wong70: Wong TW, Weiss SB, Eliceiri GL, Bryant J (1970). "Ribonucleic acid sulfurtransferase from Bacillus subtilis W168. Sulfuration with beta-mercaptopyruvate and properties of the enzyme system." Biochemistry 9(11);2376-86. PMID: 4987417


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC14B.