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MetaCyc Reaction: 4.1.1.37

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.37

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : uroporphyrinogen decarboxylase Inferred from experiment : hemE
Homo sapiens : uroporphyrinogen decarboxylase Traceable author statement to experimental support : UROD
Mus musculus : uroporphyrinogen decarboxylase Inferred from experiment : Urod
Nicotiana tabacum : uroporphyrinogen decarboxylase Inferred from experiment : UROD
Rhodobacter sphaeroides : uroporphyrinogen decarboxylase Inferred from experiment : hemE

In Pathway: heme biosynthesis I (aerobic) , chlorophyllide a biosynthesis I (aerobic, light-dependent) , heme biosynthesis II (anaerobic) , superpathway of heme biosynthesis from uroporphyrinogen-III , chlorophyllide a biosynthesis III (aerobic, light independent) , chlorophyllide a biosynthesis II (anaerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uroporphyrinogen decarboxylase

Enzyme Commission Synonyms: uroporphyrinogen III decarboxylase, porphyrinogen carboxy-lyase, porphyrinogen decarboxylase, uroporphyrinogen-III carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.3729553 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on a number of porphyrinogens.

Citations: [MAUZERALL58, Tomio70]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R03197 , Rhea:19865

Relationship Links: BRENDA:EC:4.1.1.37 , ENZYME:EC:4.1.1.37 , IUBMB-ExplorEnz:EC:4.1.1.37 , UniProt:RELATED-TO:O81220 , UniProt:RELATED-TO:P06132 , UniProt:RELATED-TO:P16891 , UniProt:RELATED-TO:P29680 , UniProt:RELATED-TO:P32347 , UniProt:RELATED-TO:P32395 , UniProt:RELATED-TO:P32920 , UniProt:RELATED-TO:P54224 , UniProt:RELATED-TO:P70697 , UniProt:RELATED-TO:Q9JV52 , UniProt:RELATED-TO:Q9PN54


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MAUZERALL58: MAUZERALL D, GRANICK S (1958). "Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase." J Biol Chem 232(2);1141-62. PMID: 13549492

Tomio70: Tomio JM, Garcia RC, San Martin de Viale LC, Grinstein M (1970). "Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties." Biochim Biophys Acta 198(2);353-63. PMID: 4984554


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu May 28, 2015, BIOCYC13A.