MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: uroporphyrinogen decarboxylaseInferred from experiment: hemE
Homo sapiens: uroporphyrinogen decarboxylaseTraceable author statement to experimental support: UROD
Mus musculus: uroporphyrinogen decarboxylaseInferred from experiment: Urod
Nicotiana tabacum: uroporphyrinogen decarboxylaseInferred from experiment: UROD
Rhodobacter sphaeroides: uroporphyrinogen decarboxylaseInferred from experiment: hemE

In Pathway: heme biosynthesis I (aerobic), chlorophyllide a biosynthesis I (aerobic, light-dependent), heme biosynthesis II (anaerobic), superpathway of heme biosynthesis from uroporphyrinogen-III, chlorophyllide a biosynthesis III (aerobic, light independent), chlorophyllide a biosynthesis II (anaerobic)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uroporphyrinogen decarboxylase

Enzyme Commission Synonyms: uroporphyrinogen III decarboxylase, porphyrinogen carboxy-lyase, porphyrinogen decarboxylase, uroporphyrinogen-III carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.3729553Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on a number of porphyrinogens.

Citations: [MAUZERALL58, Tomio70]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03197, Rhea:19865

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O81220, UniProt:RELATED-TO:P06132, UniProt:RELATED-TO:P16891, UniProt:RELATED-TO:P29680, UniProt:RELATED-TO:P32347, UniProt:RELATED-TO:P32395, UniProt:RELATED-TO:P32920, UniProt:RELATED-TO:P54224, UniProt:RELATED-TO:P70697, UniProt:RELATED-TO:Q9JV52, UniProt:RELATED-TO:Q9PN54


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MAUZERALL58: MAUZERALL D, GRANICK S (1958). "Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase." J Biol Chem 232(2);1141-62. PMID: 13549492

Tomio70: Tomio JM, Garcia RC, San Martin de Viale LC, Grinstein M (1970). "Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties." Biochim Biophys Acta 198(2);353-63. PMID: 4984554

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun Nov 29, 2015, BIOCYC11A.