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MetaCyc Reaction: 4.2.1.75

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.2.1.75

Enzymes and Genes:

Arabidopsis thaliana col : uroporphyrinogen III synthase Inferred from experiment : AT2G26540
Escherichia coli K-12 substr. MG1655 : uroporphyrinogen III synthase Inferred from experiment : hemD
Homo sapiens : uroporphyrinogen-III synthase Traceable author statement to experimental support : UROS
Rhodobacter sphaeroides : uroporphyrinogen III synthase Inferred from experiment
Triticum aestivum : uroporphyrinogen III cosynthetase Inferred from experiment

In Pathway: tetrapyrrole biosynthesis I (from glutamate) , tetrapyrrole biosynthesis II (from glycine)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uroporphyrinogen-III synthase

Enzyme Commission Synonyms: porphobilinogenase, uroporphyrinogen isomerase, uroporphyrinogen III cosynthase, URO-synthase, hydroxymethylbilane hydro-lyase (cyclizing)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.166992 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen-III from porphobilinogen.

Citations: [Tsai87, Battersby80]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R03165 , Rhea:18965

Relationship Links: BRENDA:EC:4.2.1.75 , ENZYME:EC:4.2.1.75 , IUBMB-ExplorEnz:EC:4.2.1.75 , UniProt:RELATED-TO:P09126 , UniProt:RELATED-TO:P10746 , UniProt:RELATED-TO:P21248 , UniProt:RELATED-TO:P51163 , UniProt:RELATED-TO:Q58401 , UniProt:RELATED-TO:Q59294


References

Battersby80: Battersby AR, Fookes CJ, Matcham GW, McDonald E (1980). "Biosynthesis of the pigments of life: formation of the macrocycle." Nature 285(5759);17-21. PMID: 6769048

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Tsai87: Tsai SF, Bishop DF, Desnick RJ (1987). "Purification and properties of uroporphyrinogen III synthase from human erythrocytes." J Biol Chem 262(3);1268-73. PMID: 3805019


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Sep 1, 2015, biocyc11.