Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.2.1.75

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.2.1.75

Enzymes and Genes:
uroporphyrinogen III synthase Inferred from experiment : hemD ( Escherichia coli K-12 substr. MG1655 )
uroporphyrinogen-III synthase Traceable author statement to experimental support : UROS ( Homo sapiens )
uroporphyrinogen III synthase Inferred from experiment : AT2G26540 ( Arabidopsis thaliana col )
uroporphyrinogen III cosynthetase Inferred from experiment ( Triticum aestivum )
uroporphyrinogen III synthase Inferred from experiment ( Rhodobacter sphaeroides )

In Pathway: tetrapyrrole biosynthesis I (from glutamate) , tetrapyrrole biosynthesis II (from glycine)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uroporphyrinogen-III synthase

Enzyme Commission Synonyms: porphobilinogenase, uroporphyrinogen isomerase, uroporphyrinogen III cosynthase, URO-synthase, hydroxymethylbilane hydro-lyase (cyclizing)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.166992 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen-III from porphobilinogen.

Citations: [Tsai87, Battersby80]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03165 , Rhea:18965

Relationship Links: BRENDA:EC:4.2.1.75 , ENZYME:EC:4.2.1.75 , IUBMB-ExplorEnz:EC:4.2.1.75 , UniProt:RELATED-TO:P09126 , UniProt:RELATED-TO:P10746 , UniProt:RELATED-TO:P21248 , UniProt:RELATED-TO:P51163 , UniProt:RELATED-TO:Q58401 , UniProt:RELATED-TO:Q59294


References

Battersby80: Battersby AR, Fookes CJ, Matcham GW, McDonald E (1980). "Biosynthesis of the pigments of life: formation of the macrocycle." Nature 285(5759);17-21. PMID: 6769048

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Tsai87: Tsai SF, Bishop DF, Desnick RJ (1987). "Purification and properties of uroporphyrinogen III synthase from human erythrocytes." J Biol Chem 262(3);1268-73. PMID: 3805019


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.