MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: uroporphyrinogen III synthaseInferred from experiment: AT2G26540
Escherichia coli K-12 substr. MG1655: uroporphyrinogen III synthaseInferred from experiment: hemD
Homo sapiens: uroporphyrinogen-III synthaseTraceable author statement to experimental support: UROS
Rhodobacter sphaeroides: uroporphyrinogen III synthaseInferred from experiment
Triticum aestivum: uroporphyrinogen III cosynthetaseInferred from experiment

In Pathway: tetrapyrrole biosynthesis I (from glutamate), tetrapyrrole biosynthesis II (from glycine)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uroporphyrinogen-III synthase

Enzyme Commission Synonyms: porphobilinogenase, uroporphyrinogen isomerase, uroporphyrinogen III cosynthase, URO-synthase, hydroxymethylbilane hydro-lyase (cyclizing)

Standard Gibbs Free Energy (ΔrG): -13.166992 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In the presence of EC, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen-III from porphobilinogen.

Citations: [Tsai87, Battersby80 ]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03165, Rhea:18965

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P09126, UniProt:RELATED-TO:P10746, UniProt:RELATED-TO:P21248, UniProt:RELATED-TO:P51163, UniProt:RELATED-TO:Q58401, UniProt:RELATED-TO:Q59294


Battersby80: Battersby AR, Fookes CJ, Matcham GW, McDonald E (1980). "Biosynthesis of the pigments of life: formation of the macrocycle." Nature 285(5759);17-21. PMID: 6769048

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Tsai87: Tsai SF, Bishop DF, Desnick RJ (1987). "Purification and properties of uroporphyrinogen III synthase from human erythrocytes." J Biol Chem 262(3);1268-73. PMID: 3805019

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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