Current and Filled Pathway Holes of <i>Escherichia coli</i> CFT073

Current and Filled Pathway Holes of Escherichia coli CFT073

A pathway hole is a pathway reaction for which no corresponding enzyme has been identified in the genome. We consider only contiguous pathways (pathways containing connected sets of reactions, as opposed to pathways containing unconnected sets of reactions) when enumerating pathway holes.

This report includes two tables regarding pathway holes in Escherichia coli CFT073:

Current Pathway Holes: A list of reactions within metabolic pathways of Escherichia coli CFT073 for which no corresponding enzyme has been found.

Filled Pathway Holes: A list of former pathway holes within metabolic pathways of Escherichia coli CFT073 which have been filled with the assistance of the Pathway Hole Filler.


Current Pathway Holes

This table lists reactions within metabolic pathways of Escherichia coli CFT073 for which no corresponding enzyme has been identified in the genome. The presence of those enzymes is suggested by the presence of the pathway.

88 pathway holes (8.6%) are present in the 1028 total reactions of 344 pathways

Reaction EC# Pathway(s) needing this reaction
a [lipoyl-carrier protein]-L-lysine + (octanoyl)adenylate → a [lipoyl-carrier protein] N6-octanoyl-L-lysine + AMP + 2 H+ [none] lipoate biosynthesis and incorporation II
octanoate + ATP + H+ → (octanoyl)adenylate + diphosphate [none] lipoate biosynthesis and incorporation II
a 2-acylglycerol + H2O → glycerol + a fatty acid + H+ 3.1.1.23/3.1.1.79 triacylglycerol degradation
a 1,2-diacyl-sn-glycerol + H2O → a 2-acylglycerol + a fatty acid + H+ 3.1.1.34/3.1.1.79/3.1.1.- triacylglycerol degradation
molybdopterin adenine dinucleotide + molybdate + H+ → MoO2-molybdopterin cofactor + AMP + H2O 2.10.1.1 molybdenum cofactor biosynthesis
[chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + apo-iron-sulfur protein → [chaperone-ADP]-[disordered-form scaffold protein] complex + [Fe-S cluster biosynthesis co-chaperone] + holo-[2Fe-2S] cluster protein + phosphate [none] [2Fe-2S] iron-sulfur cluster biosynthesis
[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + [Fe-S cluster biosynthesis chaperone]-ATP → [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex [none] [2Fe-2S] iron-sulfur cluster biosynthesis
[cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex + [Fe-S cluster biosynthesis co-chaperone] → [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + [L-cysteine desulfurase] [none] [2Fe-2S] iron-sulfur cluster biosynthesis
[cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex + 2 Fe3+ → [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex [none] [2Fe-2S] iron-sulfur cluster biosynthesis
S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex → [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex 2.8.1.- [2Fe-2S] iron-sulfur cluster biosynthesis
L-cysteine + [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex → L-alanine + S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex 2.8.1.7 [2Fe-2S] iron-sulfur cluster biosynthesis
S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex → [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex 2.8.1.- [2Fe-2S] iron-sulfur cluster biosynthesis
L-alanyl-γ-D-glutamyl-meso-diaminopimelate + H2O → L-alanyl-D-glutamate + meso-diaminopimelate [none] muropeptide degradation
7,8-dihydroneopterin triphosphate + H2O → 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + PPPi + 2 H+ 4.1.2.50 preQ0 biosynthesis
[HypCDE]-Fe(CO)(CN)2 + HycE → {[NiFe]-hydrogenase large subunit}-Fe(CO)(CN)2 + HypCDE trimer [none] NiFe(CO)(CN)2 cofactor biosynthesis
7,8-dihydromonapterin triphosphate + 3 H2O → 7,8-dihydromonapterin + 3 phosphate + 2 H+ [none] tetrahydromonapterin biosynthesis
D-altronate + NAD+ ← D-tagaturonate + NADH + H+ 1.1.1.58 D-galacturonate degradation I
L-arginine + H2O → urea + L-ornithine 3.5.3.1 putrescine biosynthesis III
L-ornithine + 2-oxoglutarate ↔ L-glutamate + L-glutamate-5-semialdehyde 2.6.1.13 L-arginine degradation XIII (reductive Stickland reaction)
oxidized thioredoxin + 2 e- = reduced thioredoxin [none] thioredoxin pathway
2'-deoxycytidine + a nucleoside triphosphate → dCMP + a nucleoside diphosphate + H+ 2.7.1.74 pyrimidine deoxyribonucleosides salvage
acetaldehyde + NAD+ + H2O → acetate + NADH + 2 H+ 1.2.1.3 ethanol degradation II
N-acetyl-L-ornithine + L-glutamate → L-ornithine + N-acetyl-L-glutamate 2.3.1.35 L-arginine biosynthesis II (acetyl cycle)
succinate semialdehyde + NAD(P)+ + H2O → succinate + NAD(P)H + 2 H+ 1.2.1.16 4-aminobutyrate degradation III
α-D-ribose 1,5-bisphosphate + ATP → 5-phospho-α-D-ribose 1-diphosphate + ADP 2.7.4.23 (aminomethyl)phosphonate degradation
diethylthiophosphate + H2O → diethylphosphate + hydrogen sulfide 3.13.1.- parathion degradation
acetyl-holo [citrate lyase acyl-carrier protein] + 6 H2O → holo [citrate lyase acyl-carrier protein] + 6 acetate 3.1.2.16 citrate lyase activation
holo [citrate lyase acyl-carrier protein] + S-acetyl phosphopantetheine → acetyl-holo [citrate lyase acyl-carrier protein] + 4'-phosphopantetheine 2.3.1.49 citrate lyase activation
a guanine34 in tRNA + queuine → a queuosine in tRNA + guanine 2.4.2.64
D-galactonate → 2-dehydro-3-deoxy-D-galactonate + H2O 4.2.1.6/4.2.1.140 D-galactonate degradation
lipid A disaccharide + ATP → lipid IVA + ADP + H+ 2.7.1.130 lipid IVA biosynthesis (E. coli)
L-cysteine + a [molybdopterin synthase sulfurtransferase]-L-cysteine → L-alanine + a [molybdopterin synthase sulfurtransferase]-S-sulfanyl-L-cysteine 2.8.1.7 molybdopterin biosynthesis
7,8-dihydroneopterin 3'-phosphate + H2O → 7,8-dihydroneopterin + phosphate 3.6.1.- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
(R)-3-hydroxybutanoyl-CoA + NADP+ ← acetoacetyl-CoA + NADPH + H+ 1.1.1.36 polyhydroxybutanoate biosynthesis
[oxidized DsbA protein] + a [protein]-dithiol → [reduced DsbA protein] + a [protein]-disulfide 1.8.4.-
[reduced DsbA protein] + [oxidized DsbB protein] → [oxidized DsbA protein] + [reduced DsbB protein] [none]
[reduced DsbB protein] + a quinone → [oxidized DsbB protein] + a quinol [none]
adenosine + H2O → D-ribofuranose + adenine 3.2.2.7 adenine and adenosine salvage II
dihydroxyacetone + ATP → dihydroxyacetone phosphate + ADP + H+ 2.7.1.29 glycerol degradation II
a phosphatidylserine + H+ → a phosphatidylethanolamine + CO2 4.1.1.65 phosphatidylserine and phosphatidylethanolamine biosynthesis I
2-C-methyl-D-erythritol 4-phosphate + NADP+ ← 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ 1.1.1.267 methylerythritol phosphate pathway I
S-adenosyl-L-methionine + H+ → CO2 + S-adenosyl 3-(methylthio)propylamine 4.1.1.50 spermidine biosynthesis I, aminopropylcadaverine biosynthesis
ATP + nicotinate adenine dinucleotide + L-glutamine + H2O → L-glutamate + AMP + NAD+ + diphosphate + H+ 6.3.5.1 NAD de novo biosynthesis I, NAD salvage pathway I (PNC VI cycle), NAD de novo biosynthesis IV (anaerobic)
β-nicotinamide D-ribonucleotide + H2O → D-ribofuranose 5-phosphate + nicotinamide + H+ 3.2.2.6/3.2.2.14 NAD salvage pathway I (PNC VI cycle)
NAD+ + H2O → β-nicotinamide D-ribonucleotide + AMP + 2 H+ 3.6.1.22 NAD salvage pathway I (PNC VI cycle)
dodecanoyl-[acp] + H2O → acyl-carrier protein + laurate + H+ 3.1.2.21 palmitate biosynthesis II (type II fatty acid synthase)
palmitoyl-[acp] + H2O → palmitate + acyl-carrier protein + H+ 3.1.2.14 palmitate biosynthesis II (type II fatty acid synthase)
3-dehydro-4-phospho-L-erythronate + H+ → dihydroxyacetone phosphate + CO2 4.1.1.104
ATP + 3-dehydro-L-erythronate → ADP + 3-dehydro-4-phospho-L-erythronate + H+ 2.7.1.217
2-dehydro-L-erythronate ↔ 3-dehydro-L-erythronate 5.3.1.35
L-threonate + NAD+ → 2-dehydro-L-erythronate + NADH + H+ 1.1.1.411
formaldehyde + NAD+ + H2O → formate + NADH + 2 H+ 1.2.1.46
a 5-methylaminomethyl-2-(Se-phospho)selenouridine34 in tRNA + H2O → a 5-methylaminomethyl-2-selenouridine34 in tRNA + phosphate [none] tRNA-uridine 2-thiolation and selenation (bacteria)
selenophosphate + a 5-methylaminomethyl-2-(S-geranyl)thiouridine34 in tRNA → a 5-methylaminomethyl-2-(Se-phospho)selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol [none] tRNA-uridine 2-thiolation and selenation (bacteria)
geranyl diphosphate + a 5-[(methylamino)methyl]-2-thiouridine34 in tRNA → a 5-methylaminomethyl-2-(S-geranyl)thiouridine34 in tRNA + diphosphate [none] tRNA-uridine 2-thiolation and selenation (bacteria)
acrylonitrile + H2O → acrylamide 4.2.1.84 acrylonitrile degradation I
galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate + ADP-L-glycero-β-D-manno-heptose → core oligosaccharide-lipid A (E. coli K-12 core type) (no GlcNAc) + ADP + H+ 2.4.1.- lipid A-core biosynthesis (E. coli K-12)
glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate + UDP-α-D-galactose → galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate + UDP + H+ 2.4.1.- lipid A-core biosynthesis (E. coli K-12)
stearoyl-[acp] + H2O → stearate + acyl-carrier protein + H+ 3.1.2.14 stearate biosynthesis II (bacteria and plants)
isochorismate + H2O → pyruvate + (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 3.3.2.1 2,3-dihydroxybenzoate biosynthesis
D-myo-inositol (2,4) bisphosphate + H2O → 1D-myo-inositol 2-monophosphate + phosphate 3.1.3.62 phytate degradation II
D-myo-inositol (1,2) bisphosphate + H2O → 1D-myo-inositol 2-monophosphate + phosphate 3.1.3.62 phytate degradation II
D-myo-inositol (1,2,3) trisphosphate + H2O → D-myo-inositol (1,2) bisphosphate + phosphate 3.1.3.62 phytate degradation II
D-myo-inositol (1,2,3,4,5)-pentakisphosphate + H2O → D-myo-inositol (1,2,3,4) tetrakisphosphate + phosphate 3.1.3.62 phytate degradation II
D-myo-inositol (1,2,3,4) tetrakisphosphate + H2O → D-myo-inositol (1,2,3) trisphosphate + phosphate 3.1.3.62 phytate degradation II
D-myo-inositol (1,2,3,4) tetrakisphosphate + H2O → D-myo-inositol (2,3,4) trisphosphate + phosphate 3.1.3.62 phytate degradation II
D-myo-inositol (2,3,4) trisphosphate + H2O → D-myo-inositol (2,4) bisphosphate + phosphate 3.1.3.62 phytate degradation II
a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide → a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide + di-trans,octa-cis-undecaprenyl diphosphate + H+ [none] peptidoglycan maturation (meso-diaminopimelate containing)
a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide → a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide + di-trans,octa-cis-undecaprenyl diphosphate + H+ [none] peptidoglycan maturation (meso-diaminopimelate containing)
a nascent peptidoglycan with L,D cross links (meso-diaminopimelate containing) → a mature peptidoglycan with L,D cross-links (meso-diaminopimelate containing) + di-trans,octa-cis-undecaprenyl diphosphate + H+ [none] peptidoglycan maturation (meso-diaminopimelate containing)
a nascent peptidoglycan with D,D cross-links (meso-diaminopimelate containing) → a mature peptidoglycan with D,D cross-links (meso-diaminopimelate containing) + di-trans,octa-cis-undecaprenyl diphosphate + H+ [none] peptidoglycan maturation (meso-diaminopimelate containing)
a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate) tripeptide → a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate) tripeptide + di-trans,octa-cis-undecaprenyl diphosphate + H+ [none] peptidoglycan maturation (meso-diaminopimelate containing)
a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide → a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide + di-trans,octa-cis-undecaprenyl diphosphate + H+ [none] peptidoglycan maturation (meso-diaminopimelate containing)
2 ATP + 2 [corrinoid adenosyltranferase]-cob(I)inamide + 2 H+ → 2 adenosylcobinamide + 2 PPPi + 2 [corrinoid adenosyltransferase] [none] adenosylcobinamide-GDP salvage from cobinamide I
cob(II)inamide + [corrinoid adenosyltransferase] → [corrinoid adenosyltranferase]-cob(II)inamide [none] adenosylcobinamide-GDP salvage from cobinamide I
a tetrahydrofolate + ATP + formate → an N10-formyltetrahydrofolate + ADP + phosphate 6.3.4.3 folate transformations I, folate polyglutamylation
a 5-methyltetrahydrofolate + NAD+ ← a 5,10-methylenetetrahydrofolate + NADH + H+ 1.5.1.20 folate transformations I
a (6S)-5-formyltetrahydrofolate + ATP → a 5,10-methenyltetrahydrofolate + ADP + phosphate 6.3.3.2 folate transformations I, folate transformations III (E. coli)
a 5-methyltetrahydrofolate + 2 oxidized ferredoxin [iron-sulfur] cluster ← a 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ 1.5.7.1 folate transformations I
a 5,10-methylenetetrahydrofolate + NAD+ → a 5,10-methenyltetrahydrofolate + NADH 1.5.1.15 folate transformations I
a tetrahydrofolate + trimethyl sulfonium ← dimethyl sulfide + a 5-methyltetrahydrofolate + H+ 2.1.1.19 folate transformations I
a 2,3,4-saturated fatty acid + coenzyme A + ATP → a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate 6.2.1.- fatty acid beta-oxidation I (generic)
N-(5-phosphoribosyl)-anthranilate → 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate 5.3.1.24 L-tryptophan biosynthesis
1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + H+ → (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O 4.1.1.48 L-tryptophan biosynthesis
N-acetyl-D-galactosamine 6-phosphate + H2O → D-galactosamine 6-phosphate + acetate 3.5.1.25 D-galactosamine and N-acetyl-D-galactosamine degradation
adenosylcob(III)alamin-[corrinoid adenosyltranferase] → [corrinoid adenosyltransferase] + coenzyme B12 [none] adenosylcobalamin salvage from cobalamin
[corrinoid adenosyltransferase] + cob(II)alamin → cob(II)alamin-[corrinoid adenosyltranferase] [none] adenosylcobalamin salvage from cobalamin
demethylated methyl acceptor + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + methylated methyl acceptor + H+ 2.1.1.- autoinducer AI-2 biosynthesis I

Filled Pathway Holes

Key:
Hole-filler The gene whose product is predicted to catalyze the missing reaction.
Hole EC# The EC number of the missing reaction (links to the reaction page).
P(has-function) The probability that the hole-filler catalyzes the missing reaction as determined by the PHFiller.
All functions of hole-filler All current annotations of the hole-filler, including the function of the missing reaction to which it has been assigned.
Pathway(s) requiring this reaction All metabolic pathways in which the pathway hole occurs in the database.

07:12:02 on Monday, 6/02/2025 (GMT-8)

104 pathway holes have been filled by the pathway hole filler, in 344 pathways.

Hole-filler Hole EC# P(has-function) All functions of hole-filler Pathway(s) requiring this reaction
thrA 1.1.1.3 0.998 fused aspartate kinase/homoserine dehydrogenase 1 L-homoserine biosynthesis
ribF 2.7.1.26 0.991 bifunctional riboflavin kinase / FMN adenylyltransferase flavin biosynthesis I (bacteria and plants)
ribF 2.7.7.2 0.945 bifunctional riboflavin kinase / FMN adenylyltransferase flavin biosynthesis I (bacteria and plants)
araB 2.7.1.16 1.000 ribulokinase L-arabinose degradation I
fabZ 4.2.1.59 0.962 (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase 8-amino-7-oxononanoate biosynthesis I
fabZ 4.2.1.59 0.962 (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase 8-amino-7-oxononanoate biosynthesis I
ribD 1.1.1.193 1.000 fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase flavin biosynthesis I (bacteria and plants)
ribD 3.5.4.26 0.999 fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase flavin biosynthesis I (bacteria and plants)
ispA 2.5.1.1 1.000 geranyl diphosphate/farnesyl diphosphate synthase trans, trans-farnesyl diphosphate biosynthesis, geranyl diphosphate biosynthesis
purE 5.4.99.18 1.000 N5-carboxyaminoimidazole ribonucleotide mutase inosine-5'-phosphate biosynthesis I
folD 3.5.4.9 1.000 bifunctional methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase folate transformations III (E. coli), folate transformations I, tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate
folD 1.5.1.5 1.000 bifunctional methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase folate transformations III (E. coli), folate transformations I
cobC 3.1.3.73 0.962 putative adenosylcobalamin phosphatase/α-ribazole phosphatase superpathway of adenosylcobalamin salvage from cobinamide I, adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I
fldA none 0.991 Flavodoxin 1 RXN-19339
aroG 2.5.1.54 0.945 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive 3-dehydroquinate biosynthesis I
bioC 2.1.1.197 1.000 malonyl-acyl carrier protein methyltransferase 8-amino-7-oxononanoate biosynthesis I
pyrD 1.3.5.2 0.991 dihydroorotate dehydrogenase, type 2
fabA 4.2.1.59 0.988 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (5Z)-dodecenoate biosynthesis I
fabA 5.3.3.14 0.998 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (5Z)-dodecenoate biosynthesis I
rne 3.1.26.12 0.983 ribonuclease E tRNA processing
rne 3.1.26.12 0.983 ribonuclease E tRNA processing
fabH 2.3.1.38 1.000 3-oxoacyl-[acyl carrier protein] synthase 3 superpathway of fatty acid biosynthesis initiation
thiK 2.7.1.89 0.991 thiamine kinase thiamin salvage I
nagK 2.7.1.59 0.991 N-acetyl-D-glucosamine kinase N-acetylglucosamine degradation II
dadX 5.1.1.1/5.1.1.10 1.000 alanine racemase 2 alanine racemization, alanine degradation I
tdk 2.7.1.21/2.7.1.145 1.000 thymidine/deoxyuridine kinase pyrimidine deoxyribonucleosides salvage
adhE 1.2.1.10 0.991 fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydrogenasealdehyde/alcohol dehydrogenase AdhE mixed acid fermentation, ethanolamine utilization, 2-deoxy-D-ribose degradation I, L-threonine degradation IV, ethanol degradation I, 2-deoxy-alpha-D-ribose 1-phosphate degradation, pyruvate fermentation to ethanol I
trpA 4.1.2.8 1.000 tryptophan synthase subunit α L-tryptophan biosynthesis, TRYPSYN-RXN
rnb 3.1.13.1 1.000 RNase II tRNA processing
fabI 1.3.1.9 0.981 enoyl-[acyl-carrier-protein] reductase (5Z)-dodecenoate biosynthesis I
fabI 1.3.1.9 0.981 enoyl-[acyl-carrier-protein] reductase 8-amino-7-oxononanoate biosynthesis I
fabI 1.3.1.9 0.981 enoyl-[acyl-carrier-protein] reductase 8-amino-7-oxononanoate biosynthesis I
aldA 1.2.1.21 0.991 aldehyde dehydrogenase A ethylene glycol degradation, D-arabinose degradation I
maeA 1.1.1.38 0.945 malate dehydrogenase (oxaloacetate-decarboxylating) gluconeogenesis I
folM 1.5.1.50 0.985 dihydromonapterin reductase tetrahydromonapterin biosynthesis
rnt 3.1.13.5 0.992 ribonuclease T tRNA processing
rnt 3.1.13.5 0.992 ribonuclease T tRNA processing
eda 4.1.2.14/4.1.2.55 1.000 KHG/KDPG aldolase D-galacturonate degradation I, 4-deoxy-L-threo-hex-4-enopyranuronate degradation, D-fructuronate degradation, Entner-Doudoroff shunt
nudB 3.6.1.67 0.943 dihydroneopterin triphosphate diphosphatase 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
hisB 3.1.3.15 1.000 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase L-histidine biosynthesis
hisB 4.2.1.19 1.000 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase L-histidine biosynthesis
hisI 3.6.1.31 1.000 putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase L-histidine biosynthesis
hisI 3.5.4.19 1.000 putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase L-histidine biosynthesis
thiD 2.7.1.49 1.000 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase hydroxymethylpyrimidine salvage
folC 6.3.2.12 0.991 bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase tetrahydrofolate biosynthesis I
fabB 2.3.1.41/2.3.1.179 0.991 3-oxoacyl-[acyl carrier protein] synthase 1 8-amino-7-oxononanoate biosynthesis I
fadJ 5.3.3.8 0.996 multifunctional 3-hydroxyacyl-CoA dehydrogenase/3-hydroxyacyl-CoA epimerase/enoyl-CoA hydratase FadJ fatty acid beta-oxidation I (generic), fatty acid beta-oxidation III (unsaturated, odd number)
fadJ 5.1.2.3 0.996 multifunctional 3-hydroxyacyl-CoA dehydrogenase/3-hydroxyacyl-CoA epimerase/enoyl-CoA hydratase FadJ fatty acid beta-oxidation I (generic)
fadJ 1.1.1.35 1.000 multifunctional 3-hydroxyacyl-CoA dehydrogenase/3-hydroxyacyl-CoA epimerase/enoyl-CoA hydratase FadJ fatty acid beta-oxidation I (generic)
guaA 6.3.5.2 1.000 GMP synthetase guanosine ribonucleotides de novo biosynthesis
guaA none 1.000 GMP synthetase GMP-SYN-GLUT-RXN
pheA 4.2.1.51 0.999 fused chorismate mutase/prephenate dehydratase L-phenylalanine biosynthesis I
tyrA 1.3.1.12 0.983 fused chorismate mutase/prephenate dehydrogenase L-tyrosine biosynthesis I
luxS 4.4.1.21 0.998 S-ribosylhomocysteine lyase S-adenosyl-L-methionine salvage I, autoinducer AI-2 biosynthesis I
queF 1.7.1.13 0.991 7-cyano-7-deazaguanine reductase queuosine biosynthesis
kduD 1.1.1.127 1.000 2-keto-3-deoxy-D-gluconate dehydrogenase 4-deoxy-L-threo-hex-4-enopyranuronate degradation
hldE 2.7.1.167 0.991 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase ADP-L-glycero-beta-D-manno-heptose biosynthesis
hldE 2.7.7.70 0.991 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase ADP-L-glycero-beta-D-manno-heptose biosynthesis
uxaA 4.2.1.7 0.999 D-altronate dehydratase D-galacturonate degradation I
kdsC 3.1.3.45 0.991 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC CMP-3-deoxy-D-manno-octulosonate biosynthesis
nanK 2.7.1.60 0.999 N-acetylmannosamine kinase N-acetylneuraminate and N-acetylmannosamine degradation I
nanE 5.1.3.9 0.999 probable N-acetylmannosamine-6-phosphate 2-epimerase N-acetylneuraminate and N-acetylmannosamine degradation I
mdh 1.1.1.37 1.000 malate dehydrogenase mixed acid fermentation, TCA cycle I (prokaryotic), gluconeogenesis I, 1.1.1.39-RXN, glyoxylate cycle
argD 2.6.1.17 0.991 N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase L-lysine biosynthesis I
bioH 3.1.1.85 0.981 pimeloyl-acyl carrier protein methyl ester esterase 8-amino-7-oxononanoate biosynthesis I
glgX 3.2.1.196 0.999 limit dextrin α-1,6-glucohydrolase glycogen degradation I
ghrB 1.1.1.- 1.000 glyoxylate reductase ketogluconate metabolism
lldD 1.1.5.- 0.991 L-lactate dehydrogenase L-lactaldehyde degradation (aerobic)
waaY 2.7.1.- 0.986 lipopolysaccharide core heptose (II) kinase lipid A-core biosynthesis (E. coli K-12)
waaO 2.4.1.73 1.000 UDP-D-glucose:(glucosyl)LPS α-1,3-glucosyltransferase lipid A-core biosynthesis (E. coli K-12)
waaP 2.7.1.- 0.999 lipopolysaccharide core heptose (I) kinase
waaG 2.4.1.- 0.999 lipopolysaccharide glucosyltransferase I
waaQ 2.4.-.- 0.999 lipopolysaccharide core heptosyltransferase 3
waaA 2.4.99.13 1.000 KDO transferase Kdo transfer to lipid IVA (E. coli)
dfp 4.1.1.36 0.991 fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase coenzyme A biosynthesis I (bacteria)
dfp 6.3.2.5 0.983 fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase coenzyme A biosynthesis I (bacteria)
spoT 2.7.6.5 1.000 bifunctional (p)ppGpp synthase/hydrolase SpoT ppGpp biosynthesis
rnpA 3.1.26.5 0.995 RNase P protein component tRNA processing
rffC 2.3.1.210 0.999 dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase dTDP-N-acetylthomosamine biosynthesis
wecE 2.6.1.59 0.999 dTDP-4-dehydro-6-deoxy-D-glucose transaminase dTDP-N-acetylthomosamine biosynthesis
ubiE 2.1.1.201 0.981 bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinol methylase and demethylmenaquinone methyltransferase ubiquinol-8 biosynthesis (early decarboxylation)
hemG 1.3.5.3 0.991 protoporphyrinogen oxidase heme b biosynthesis II (oxygen-independent)
ppc 4.1.1.31 1.000 phosphoenolpyruvate carboxylase mixed acid fermentation
birA 6.3.4.15 0.954 DNA-binding transcriptional repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA biotin-carboxyl carrier protein assembly
thiH 4.1.99.19 0.999 2-iminoacetate synthase thiazole component of thiamine diphosphate biosynthesis I
thiG 2.8.1.10 1.000 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase thiazole component of thiamine diphosphate biosynthesis I
thiF 2.7.7.73 1.000 sulfur carrier protein ThiS adenylyltransferase thiazole component of thiamine diphosphate biosynthesis I
thiC 4.1.99.17 0.999 phosphomethylpyrimidine synthase 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I
purH 2.1.2.3 1.000 bifunctional AICAR transformylase/IMP cyclohydrolase inosine-5'-phosphate biosynthesis I
purH 3.5.4.10 1.000 bifunctional AICAR transformylase/IMP cyclohydrolase inosine-5'-phosphate biosynthesis I
c5035 1.8.1.4 1.000 Putative 2-oxoglutarate dehydrogenase 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate decarboxylation to succinyl-CoA
rpiB 5.3.1.- 0.962 allose-6-phosphate isomerase / ribose-5-phosphate isomerase B D-allose degradation
deoA 2.4.2.2/2.4.2.3 1.000 thymidine phosphorylase pyrimidine deoxyribonucleosides degradation
deoD 2.4.2.1 1.000 purine nucleoside phosphorylase purine deoxyribonucleosides degradation I
deoD 2.4.2.1 1.000 purine nucleoside phosphorylase purine deoxyribonucleosides degradation I
deoD 2.4.2.1 1.000 purine nucleoside phosphorylase purine deoxyribonucleosides degradation I

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