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| Tier 1 Highly Curated Organism Database Escherichia coli K-12 substr. MG1655 | |
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| Summary | EcoCyc is a model-organism database for Escherichia coli K-12 MG1655, the strain from which the first complete genome sequence was obtained for E. coli [Blattner97]. The source of the original K-12 isolate came from a stool sample from a patient with diptheria in 1922, but the name, K-12, is more difficult to pin down (see Microbiology Today, Escherichia coli and Small Things Considered, How did E. coli get named K-12?). The genome sequences used in EcoCyc have been updated from the original Blattner et al. sequence through a collaboration between EcoCyc, the University of Wisconsin, UniProtKB/Swiss-Prot, and the National Center for Biotechnology Information (NCBI). The E. coli genome sequence used in EcoCyc currently was updated from version 2 to version 3, GenBank accession number U00096.3, at release 20.0 of EcoCyc. Annotation updates to the NCBI U00096.3 from EcoCyc are ongoing. However, despite the involvement of EcoCyc staff in these ongoing updates to the U00096 record, some annotation differences may be found, such as due to recent updates to EcoCyc. EcoCyc also collaborates with the Gene Ontology Consortium and UniProtKB to maintain consistency between the databases. For more information, see EcoCyc.org and the link to Project Overview. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genome |
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| Database Contents |
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| Database Version | 29.5 [History of Updates] |
| Taxonomic Lineage | cellular organisms Bacteria <bacteria> Pseudomonadati Pseudomonadota Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia coli Escherichia coli K-12 Escherichia coli K-12 substr. MG1655 |
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| Genetic Code Number | 11 -- Bacterial, Archaeal and Plant Plastid (same as Standard, except for alternate initiation codons) |
| GOLD | Gp0072557 |
| NCBI-Taxonomy | 511145 |
| Geographic Location | Palo Alto, CA |
| Relationship to Oxygen | facultative |
| Trophic Level | heterotroph |
| Temperature Range | mesophile |
| Biotic Relationship | symbiont |
| Pathogenicity | human |
| Host | Homo sapiens |
| NCBI Genome Type | reference |
References
Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Frontiers in Microbiology 2021
Page generated by Pathway Tools version 29.5 (software by SRI International) on Sat Feb 7, 2026, BIOCYC14.
