BioCyc Support for Synthetic Biology

BioCyc supports the data and analytical needs of the synthetic biology community in multiple respects.

Chassis Genome Databases: BioCyc provides high-quality curated databases for the major synthetic biology chassis organisms. Each database combines the sequenced genome of an organism with its metabolic pathways, reactions, enzymes, and metabolites, and with additional organism-specific data such as the genetic regulatory network and essential genes.

Universal Pathway Database: The MetaCyc database contains 3,200 metabolic pathways from all domains of life, as well as 19,000 metabolic reactions and 14,000 enzymes. Curated from 77,000 publications, MetaCyc is a comprehensive metabolic parts catalog, listing metabolic enzymes that can be engineered into other organisms. MetaCyc provides extensive enzyme data including subunit composition, cofactors, activators, inhibitors, and kinetic parameters.

Software Tools for Pathway Design and More: BioCyc provides more than 40 software tools, ranging from a genome browser to a metabolic network browser to unique tools for comparative analysis and omics data analysis. The BioCyc RouteSearch tool designs novel metabolic pathways – given a starting metabolite and an ending metabolite, RouteSearch finds a minimal-cost path from the starting to the ending metabolite.

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