Escherichia coli K-12 substr. MG1655 cysG

gene

enzyme

Accession IDs	EG10188 (EcoCyc) b3368 ECK3356 P0AEA8 (UniProt)	Length	1374 bp / 457 aa
		Map Position	[3,497,828 -> 3,499,201] (75.36 centisomes, 271°)
		Location	cytosol
Reactions	2.1.1.107: 2 S-adenosyl-L-methionine + uroporphyrinogen-III → 2 S-adenosyl-L-homocysteine + precorrin-2 + H⁺ S-adenosyl-L-methionine + precorrin-1 → S-adenosyl-L-homocysteine + precorrin-2 S-adenosyl-L-methionine + uroporphyrinogen-III → S-adenosyl-L-homocysteine + precorrin-1 + H⁺ + 2 more 1.3.1.76: precorrin-2 + NAD⁺ → sirohydrochlorin + NADH + 2 H⁺ 4.99.1.4: sirohydrochlorin + Fe²⁺ → siroheme + 2 H⁺ [Show fewer]
Pathway	siroheme biosynthesis
Evidence	Inferred by functional complementation [Warren94] Assay of protein purified to homogeneity [Woodcock96] Assay of protein purified to homogeneity from its native host [Spencer93a, Warren90a]