Escherichia coli K-12 substr. MG1655 pyruvate dehydrogenase E2 subunit

gene

enzyme

Synonym	dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Accession IDs	EG10025 (EcoCyc) b0115 ECK0114 P06959 (UniProt)	Length	1893 bp / 630 aa
		Map Position	[125,695 -> 127,587] (2.71 centisomes, 10°)
		Location	cytosol
Reactions	1.2.1.104: pyruvate + coenzyme A + NAD⁺ → acetyl-CoA + CO₂ + NADH (catalyzed by complex) 2.3.1.12: acetyl-CoA + a [pyruvate dehydrogenase E2 protein] N⁶-dihydrolipoyl-L-lysine ← coenzyme A + a [pyruvate dehydrogenase E2 protein] N⁶-S-acetyldihydrolipoyl-L-lysine pyruvate dehydrogenase E2 subunit + lipoyl-ACP = lipoyl-[pyruvate dehydrogenase E2 sbunit] + acyl-carrier protein + 2 more [(R)-lipoyl]adenylate + pyruvate dehydrogenase E2 subunit → lipoyl-[pyruvate dehydrogenase E2 sbunit] + diphosphate 6.3.1.20: ATP + pyruvate dehydrogenase E2 subunit + (R)-lipoate → AMP + lipoyl-[pyruvate dehydrogenase E2 sbunit] + diphosphate [Show fewer]
Pathways	superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass pyruvate decarboxylation to acetyl CoA I
Evidence	Inferred from mutant phenotype [Russell92]